Gene Symbol | Bcl11b |
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Entrez Gene | 58208 |
Alt Symbol | 9130430L19Rik, AI604821, B630002E05Rik, BCL-11B, Ctip2, Rit1 |
Species | Mouse |
Gene Type | protein-coding |
Description | B cell leukemia/lymphoma 11B |
Other Description | B-cell CLL/lymphoma 11B|B-cell leukemia/lymphoma 11B|B-cell lymphoma/leukaemia 11B|B-cell lymphoma/leukemia 11B|COUP-TF interacting protein 2|COUP-TF-interacting protein 2|mRit1|radiation-induced tumor suppressor gene 1 protein |
Swissprots | Q9JLF8 Q8C2I1 Q99PV8 Q99PV7 Q99PV6 |
Accessions | EDL18728 EDL18729 Q99PV8 AB043551 BAB32728 AB043553 BAB32729 AB043583 BAB32730 AF186019 AAF63683 AK020296 AK080974 AK088219 AK088588 BAC40438 AK140184 AK169655 BAE41279 BC019503 AAH19503 BM950501 BQ442983 BQ745012 CV563304 XM_006516110 XP_006516173 XM_006516111 XP_006516174 XM_006516113 XP_006516176 XM_006516114 XP_006516177 XM_006516115 XP_006516178 XM_006516116 XP_006516179 XM_011244152 XP_011242454 XM_011244153 XP_011242455 NM_001079883 NP_001073352 NM_001286343 NP_001273272 NM_021399 NP_067374 |
Function | Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element. {ECO:0000269|PubMed:12717433}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed in brain and thymus. |
Bcl-11b CRISPR/Cas9 KO Plasmid (m) - sc-425486 from Santa Cruz Biotechnology
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Bcl-11b HDR Plasmid (m) - sc-425486-HDR from Santa Cruz Biotechnology
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Bcl-11b Double Nickase Plasmid (m) - sc-425486-NIC from Santa Cruz Biotechnology
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Bcl-11b Double Nickase Plasmid (m2) - sc-425486-NIC-2 from Santa Cruz Biotechnology
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Bcl-11b CRISPR Activation Plasmid (m) - sc-425486-ACT from Santa Cruz Biotechnology
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Bcl-11b CRISPR Activation Plasmid (m2) - sc-425486-ACT-2 from Santa Cruz Biotechnology
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Bcl-11b Lentiviral Activation Particles (m) - sc-425486-LAC from Santa Cruz Biotechnology
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Bcl-11b Lentiviral Activation Particles (m2) - sc-425486-LAC-2 from Santa Cruz Biotechnology
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Bcl-11b siRNA (m) - sc-44942 from Santa Cruz Biotechnology
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Bcl-11b shRNA Plasmid (m) - sc-44942-SH from Santa Cruz Biotechnology
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Bcl-11b shRNA (m) Lentiviral Particles - sc-44942-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU153651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27554 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27554 from Sigma-Aldrich
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BCL11B siRNA (Mouse) - CRM6102 from Cohesion Biosciences
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BCL11B - MBS8218250 from MyBioSource
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shRNA set against Mouse Bcl11b (NM_021399.2) - SHH245874 from Creative biogene
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shRNA set against Mouse Bcl11b(NM_021399.2) - SHG096821 from Creative biogene
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shRNA set against Mouse Bcl11b(NM_001079883.1) - SHG096857 from Creative biogene
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Mouse BCL11B siRNA - orb285578 from Biorbyt
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BCL11B shRNA Plasmid (Mouse) - CHM6102 from Cohesion Biosciences
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BCL11B miRNA 3'UTR clone - MiUTR1M-02153 from Creative biogene
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BCL11B miRNA 3'UTR clone - MiUTR1M-02154 from Creative biogene
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