Gene Symbol | PPP6R1 |
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Entrez Gene | 22870 |
Alt Symbol | KIAA1115, PP6R1, SAP190, SAPS1 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 6, regulatory subunit 1 |
Other Description | SAPS domain family, member 1|serine/threonine-protein phosphatase 6 regulatory subunit 1 |
Swissprots | Q9BU97 Q6NVJ6 Q504V2 Q9UPN7 Q2M2H3 |
Accessions | EAW72352 EAW72353 EAW72354 Q9UPN7 AB029038 BAA83067 AK126810 AK297152 BAG59651 AL544921 BC002799 AAH02799 BC007629 AAH07629 BC068014 AAH68014 BC094753 AAH94753 BC111980 BC113443 BG772019 BX362839 NM_014931 NP_055746 |
Function | Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. {ECO:0000269|PubMed:16769727}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:18186651}. |
Tissue Specificity | Ubiquitous with higher expression in testis. {ECO:0000269|PubMed:16769727}. |
SAPS1 CRISPR/Cas9 KO Plasmid (h) - sc-406315 from Santa Cruz Biotechnology
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SAPS1 HDR Plasmid (h) - sc-406315-HDR from Santa Cruz Biotechnology
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SAPS1 Double Nickase Plasmid (h) - sc-406315-NIC from Santa Cruz Biotechnology
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SAPS1 Double Nickase Plasmid (h2) - sc-406315-NIC-2 from Santa Cruz Biotechnology
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SAPS1 CRISPR Activation Plasmid (h) - sc-406315-ACT from Santa Cruz Biotechnology
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SAPS1 CRISPR Activation Plasmid (h2) - sc-406315-ACT-2 from Santa Cruz Biotechnology
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SAPS1 Lentiviral Activation Particles (h) - sc-406315-LAC from Santa Cruz Biotechnology
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SAPS1 Lentiviral Activation Particles (h2) - sc-406315-LAC-2 from Santa Cruz Biotechnology
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SAPS1 siRNA (h) - sc-97773 from Santa Cruz Biotechnology
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SAPS1 shRNA Plasmid (h) - sc-97773-SH from Santa Cruz Biotechnology
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SAPS1 shRNA (h) Lentiviral Particles - sc-97773-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU019831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17316 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17316 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06214 from Sigma-Aldrich
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PPP6R1 siRNA (Human) - CRH7827 from Cohesion Biosciences
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SAPS1 CRISPR/Cas9 KO Plasmid (h2) - sc-406315-KO-2 from Santa Cruz Biotechnology
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SAPS1 HDR Plasmid (h2) - sc-406315-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PPP6R1 (NM_014931.3) - SHH381664 from Creative biogene
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shRNA set against Human SAPS1(NM_014931.3) - SHR204848 from Creative biogene
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Human PPP6R1 siRNA - orb268329 from Biorbyt
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PPP6R1 shRNA Plasmid (Human) - CHH7827 from Cohesion Biosciences
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PPP6R1 miRNA 3'UTR clone - MiUTR1H-09137 from Creative biogene
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