| Gene Symbol |
ENOX2
|
| Entrez Gene |
10495
|
| Alt Symbol |
APK1, COVA1, tNOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ecto-NOX disulfide-thiol exchanger 2
|
| Other Description |
APK1 antigen|cytosolic ovarian carcinoma antigen 1|tumor-associated hydroquinone oxidase
|
| Swissprots |
A8K1C2 Q5VTJ2 Q16206 Q5VTJ1 Q9UH82 A8K197 Q8WUX0 Q9NTP6
|
| Accessions |
CAM12255 EAX11796 EAX11797 Q16206 AF207881 AAF20934 AI540639 AK000353 AK289812 BAF82501 AK289837 BAF82526 AL133207 CAB61581 BC019254 AAH19254 BC108713 AAI08714 BC139781 AAI39782 BC140874 AAI40875 BU160341 DB128861 S72904 AAB30428 XM_005262354 XP_005262411 XM_011531244 XP_011529546 XM_011531245 XP_011529547 XM_011531246 XP_011529548 XM_011531247 XP_011529549 XM_011531248 XP_011529550 XM_011531249 XP_011529551 XM_011531250 XP_011529552 XM_011531251 XP_011529553 XM_011531252 XP_011529554 NM_001281736 NP_001268665 NM_006375 NP_006366 NM_182314 NP_872114
|
| Function |
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}.
|
| Subcellular Location |
Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
|
| Tissue Specificity |
Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
|