Gene Symbol | ERC2 |
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Entrez Gene | 26059 |
Alt Symbol | CAST, CAST1, ELKSL, SPBC110, Spc110 |
Species | Human |
Gene Type | protein-coding |
Description | ELKS/RAB6-interacting/CAST family member 2 |
Other Description | CAZ-associated structural protein|ERC protein 2|cytomatrix protein p110 |
Swissprots | Q2T9F6 O15083 Q86TK4 |
Accessions | EAW65315 EAW65316 O15083 AB002376 BAA20832 BC060881 BC068563 BC094783 BC111550 AAI11551 BC112391 AAI12392 XM_011533580 XP_011531882 XM_011533581 XP_011531883 XM_011533582 XP_011531884 XR_245112 XR_245114 NM_015576 NP_056391 |
Function | Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12923177}. Cell junction, synapse {ECO:0000269|PubMed:12923177}. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:12923177}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12923177}. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). {ECO:0000250}. |
ERC2 CRISPR/Cas9 KO Plasmid (h) - sc-407488 from Santa Cruz Biotechnology
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ERC2 HDR Plasmid (h) - sc-407488-HDR from Santa Cruz Biotechnology
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ERC2 Double Nickase Plasmid (h) - sc-407488-NIC from Santa Cruz Biotechnology
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ERC2 Double Nickase Plasmid (h2) - sc-407488-NIC-2 from Santa Cruz Biotechnology
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ERC2 CRISPR Activation Plasmid (h) - sc-407488-ACT from Santa Cruz Biotechnology
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ERC2 CRISPR Activation Plasmid (h2) - sc-407488-ACT-2 from Santa Cruz Biotechnology
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ERC2 Lentiviral Activation Particles (h) - sc-407488-LAC from Santa Cruz Biotechnology
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ERC2 Lentiviral Activation Particles (h2) - sc-407488-LAC-2 from Santa Cruz Biotechnology
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ERC2 siRNA (h) - sc-77281 from Santa Cruz Biotechnology
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ERC2 shRNA Plasmid (h) - sc-77281-SH from Santa Cruz Biotechnology
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ERC2 shRNA (h) Lentiviral Particles - sc-77281-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU160201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7948 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7948 from Sigma-Aldrich
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ERC2 siRNA (Human) - CRH8688 from Cohesion Biosciences
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ERC2 - MBS8219045 from MyBioSource
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shRNA set against Human ERC2 (NM_015576.1) - SHH286865 from Creative biogene
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shRNA set against Human ERC2(NM_015576.1) - SHH038045 from Creative biogene
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ERC2 shRNA Plasmid (Human) - CHH8688 from Cohesion Biosciences
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ERC2 miRNA 3'UTR clone - MiUTR1H-03288 from Creative biogene
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