ACVR1B

Gene Symbol	ACVR1B
Entrez Gene	91
Alt Symbol	ACTRIB, ACVRLK4, ALK4, SKR2
Species	Human
Gene Type	protein-coding
Description	activin A receptor, type IB
Other Description	activin A receptor, type II-like kinase 4|activin receptor type-1B|activin receptor-like kinase 4|serine/threonine-protein kinase receptor R2
Swissprots	Q15481 B7Z5W5 B7Z5L8 Q15480 P36896 Q15482 Q15479
Accessions	AAA53349 AAA53350 AAA53351 EAW58216 EAW58217 EAW58218 P36896 AK299120 BAH12954 AK299496 BAH13051 AL117643 BC000254 AAH00254 BC034008 BC040531 AAH40531 BT007072 AAP35735 EU831986 ACE87427 EU832079 ACE86741 L10125 AAA60555 L10126 AAA60556 U14722 AAA50246 Z22536 CAA80258 XM_011538966 XP_011537268 XM_011538967 XP_011537269 NM_004302 NP_004293 NM_020327 NP_064732 NM_020328 NP_064733
Function	Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as AC
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Top Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active Activin A Receptor Type IB protein fragment - ab55682 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells

Active human Activin A Receptor Type IB protein fragment - ab182676 from Abcam Category Protein Prices $357.00 Sizes 200 µg Source HEK 293 cells Species Human

Human Activin A Receptor Type IB full length protein - ab132045 from Abcam Category Protein Source Wheat germ Species Human

Human Activin A Receptor Type IB protein fragment - ab157846 from Abcam Category Protein Source Wheat germ Species Human

ACVR1B / ALK4 Antibody Blocking Peptide - LS-E9270 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACVR1B / ALK4 Antibody Blocking Peptide - LS-E9271 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACVR1B / ALK4 Antibody Blocking Peptide - LS-E30568 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Activin RIB/ALK-4 Partial Recombinant Protein - H00000091-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Activin RIB/ALK-4 Protein - H00000091-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Activin RIB/ALK-4 Peptide - NBP1-76351PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Activin RIB/ALK-4 Peptide - P2802 from Novus Biologicals Category Peptide Species Human

Activin RIB/ALK-4 Peptide - P2801 from Novus Biologicals Category Peptide Species Human

Activin-A-Receptor-Type-IB-ACVR1B-Antibody-Center-Blocking-peptide - BP7801c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Activin-A-Receptor-Type-IB-ACVR1B-Antibody-N-term-Blocking-peptide - BP7801a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Activin RIB/ALK-4 Fc Chimera, CF - 808-AR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human ALK4 Fc His tag protein - orb84054 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 100 μg, 200 μg Source Human Species Human

Human ALK4 His tag protein - orb83522 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

ACVR1B Blocking Peptide - abx062208 from Abbexa Category Peptide Species Human, Mouse, Rat

Human ACVR1B Protein - abx065136 from Abbexa Category Protein Source E.coli Species Human

Activin receptor type 1B (ACVR1B) - H00000091-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Activin receptor type 1B (ACVR1B) - H00000091-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Activin receptor type 1B (ACVR1B) - H00000091-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Activin receptor type 1B (ACVR1B) - H00000091-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Activin receptor type 1B (ACVR1B) - P5492 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Activin receptor type 1B (ACVR1B) Control Peptide - AP30015CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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