Gene Symbol | CLDN6 |
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Entrez Gene | 9074 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | claudin 6 |
Other Description | claudin-6|skullin |
Swissprots | D3DUA5 P56747 B3KQP9 |
Accessions | CAB56533 CAI72055 EAW85431 EAW85432 P56747 AF125306 AAK02013 AK075329 BAG52111 AY358480 AAQ88844 BC008934 AAH08934 BT007399 AAP36063 BX444798 CN420342 NM_021195 NP_067018 |
Function | Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells. {ECO:0000250, ECO:0000269|PubMed:17804490}. |
Subcellular Location | Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. {ECO:0000269|PubMed:17804490}. |
Top Pathways | Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C |
claudin-6 CRISPR/Cas9 KO Plasmid (h) - sc-403405 from Santa Cruz Biotechnology
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claudin-6 HDR Plasmid (h) - sc-403405-HDR from Santa Cruz Biotechnology
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claudin-6 Double Nickase Plasmid (h) - sc-403405-NIC from Santa Cruz Biotechnology
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claudin-6 Double Nickase Plasmid (h2) - sc-403405-NIC-2 from Santa Cruz Biotechnology
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claudin-6 CRISPR Activation Plasmid (h) - sc-403405-ACT from Santa Cruz Biotechnology
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claudin-6 CRISPR Activation Plasmid (h2) - sc-403405-ACT-2 from Santa Cruz Biotechnology
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claudin-6 Lentiviral Activation Particles (h) - sc-403405-LAC from Santa Cruz Biotechnology
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claudin-6 Lentiviral Activation Particles (h2) - sc-403405-LAC-2 from Santa Cruz Biotechnology
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claudin-6 siRNA (h) - sc-43046 from Santa Cruz Biotechnology
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claudin-6 shRNA Plasmid (h) - sc-43046-SH from Santa Cruz Biotechnology
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claudin-6 shRNA (h) Lentiviral Particles - sc-43046-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU049921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6190 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6190 from Sigma-Aldrich
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CLDN6 siRNA (Human) - CRH5990 from Cohesion Biosciences
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CLDN6 - MBS828228 from MyBioSource
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shRNA set against Human CLDN6 (NM_021195.4) - SHH264821 from Creative biogene
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Human CLDN6 siRNA - orb266492 from Biorbyt
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CLDN6 shRNA Plasmid (Human) - CHH5990 from Cohesion Biosciences
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CLDN6 miRNA 3'UTR clone - MiUTR1H-02194 from Creative biogene
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