| Gene Symbol |
MNDA
|
| Entrez Gene |
4332
|
| Alt Symbol |
PYHIN3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myeloid cell nuclear differentiation antigen
|
| Other Description |
-
|
| Swissprots |
P41218
|
| Accessions |
EAW52807 EAW52808 P41218 AK290392 BAF83081 AK313210 BAG36026 BC020715 AAH20715 BC032319 AAH32319 M81750 AAA69696 NM_002432 NP_002423
|
| Function |
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
|
| Tissue Specificity |
Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia. {ECO:0000269|PubMed:8175894}.
|
![Western Blot: MNDA Overexpression Lysate (Adult Normal) [NBL1-13165] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MNDA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7550_MNDA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13165-img0002.jpg)