ATP5A1
| Gene Symbol | ATP5A1 |
|---|---|
| Entrez Gene | 498 |
| Alt Symbol | ATP5A, ATP5AL2, ATPM, COXPD22, HEL-S-123m, MC5DN4, MOM2, OMR, ORM, hATP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
| Other Description | ATP synthase alpha chain, mitochondrial|ATP synthase subunit alpha, mitochondrial|ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle|ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2|ATP sythase (F1-ATPase) alpha subunit|epididymis secretory sperm binding protein Li 123m|mitochondrial ATP synthetase, oligomycin-resistant |
| Swissprots | A8K092 Q96IR6 B4DY56 Q53XX6 K7ENP3 Q9BTV8 Q8IXV2 Q96HW2 P25705 Q96FB4 |
| Accessions | BAA05672 CAA48804 EAX01471 P25705 AK092735 BAG52604 AK098765 AK129739 AK129804 AK129900 AK289457 BAF82146 AK294804 BAG57924 AK302272 BAG63618 AK310051 AU120644 AU143001 AW205533 AW207528 BC003119 AAH03119 BC007299 AAH07299 BC008028 AAH08028 BC011384 AAH11384 BC016046 AAH16046 BC019310 AAH19310 BC028335 BC035703 BC039135 AAH39135 BC042694 BC064562 AAH64562 BC067385 AAH67385 BT007209 AAP35873 BT008250 AAP36942 CD244623 CK002707 D14710 BAA03531 DQ890557 ABM92174 DQ894210 ABM85136 FJ224309 ACI46001 X59066 CAA41789 X65460 CAA46452 XM_011526018 XP_011524320 NM_001001935 NP_001001935 NM_001001937 NP_001001937 NM_001257334 NP_001244263 NM_001257335 NP_001244264 NM_004046 NP_004037 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Colocalizes with HRG on the cell surface of T-cells. |
| Tissue Specificity | Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord. {ECO:0000269|PubMed:8428659}. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
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