| Gene Symbol |
TRIP10
|
| Entrez Gene |
9322
|
| Alt Symbol |
CIP4, HSTP, STOT, STP, TRIP-10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor interactor 10
|
| Other Description |
TR-interacting protein 10|cdc42-interacting protein 4|protein Felic|salt tolerant protein|salt tolerator|thyroid receptor-interacting protein 10
|
| Swissprots |
Q5TZN1 Q15642 D6W645 Q8TDX3 O15184 B7WP22 Q8NFL1 Q53G22 Q6FI24 Q96RJ1 B2R8A6 Q8TCY1
|
| Accessions |
EAW69060 EAW69061 EAW69062 EAW69063 EAW69064 EAW69065 Q15642 AB007845 BAF80144 AB072596 BAB88853 AF380114 AAK77492 AF502289 AAM46851 AJ000414 CAA04062 AK223109 BAD96829 AK313296 BAG36103 AL832186 AY081141 AAL89588 BC013002 AAH13002 BG494851 BQ931996 BT006698 AAP35344 BT020167 AAV38969 BT020171 AAV43773 CB997985 CR536513 CAG38751 DB198268 DQ892747 ABM83673 DQ895993 ABM86961 L40379 AAC41729 XM_005259683 XP_005259740 XM_006722940 XP_006723003 NM_001288962 NP_001275891 NM_001288963 NP_001275892 NM_004240 NP_004231 NR_110231
|
| Function |
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F- actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. {ECO:0000269|PubMed:11294612, ECO:0000269|PubMed:12054674, ECO:0000269|PubMed:12456510, ECO:0000269|PubMed:12604778, ECO:0000269|PubMed:9210375}.
|
| Top Pathways |
Insulin signaling pathway
|
![Western Blot: Cip4 Overexpression Lysate (Adult Normal) [NBP2-10575] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cip4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2148_Cip4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10575-img0001.jpg)