TRIP10

Gene Symbol	TRIP10
Entrez Gene	9322
Alt Symbol	CIP4, HSTP, STOT, STP, TRIP-10
Species	Human
Gene Type	protein-coding
Description	thyroid hormone receptor interactor 10
Other Description	TR-interacting protein 10|cdc42-interacting protein 4|protein Felic|salt tolerant protein|salt tolerator|thyroid receptor-interacting protein 10
Swissprots	Q5TZN1 Q15642 D6W645 Q8TDX3 O15184 B7WP22 Q8NFL1 Q53G22 Q6FI24 Q96RJ1 B2R8A6 Q8TCY1
Accessions	EAW69060 EAW69061 EAW69062 EAW69063 EAW69064 EAW69065 Q15642 AB007845 BAF80144 AB072596 BAB88853 AF380114 AAK77492 AF502289 AAM46851 AJ000414 CAA04062 AK223109 BAD96829 AK313296 BAG36103 AL832186 AY081141 AAL89588 BC013002 AAH13002 BG494851 BQ931996 BT006698 AAP35344 BT020167 AAV38969 BT020171 AAV43773 CB997985 CR536513 CAG38751 DB198268 DQ892747 ABM83673 DQ895993 ABM86961 L40379 AAC41729 XM_005259683 XP_005259740 XM_006722940 XP_006723003 NM_001288962 NP_001275891 NM_001288963 NP_001275892 NM_004240 NP_004231 NR_110231
Function	Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F- actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.
Tissue Specificity	Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. {ECO:0000269|PubMed:11294612, ECO:0000269|PubMed:12054674, ECO:0000269|PubMed:12456510, ECO:0000269|PubMed:12604778, ECO:0000269|PubMed:9210375}.
Top Pathways	Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cip4 full length protein - ab132255 from Abcam Category Protein Source Wheat germ Species Human

Human Cip4 protein fragment - ab174408 from Abcam Category Protein Source E. coli Species Human

TRIP10 / CIP4 Antibody Blocking Peptide - LS-E3206 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIP10 / CIP4 Antibody Blocking Peptide - LS-E12100 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIP10 / CIP4 Antibody Blocking Peptide - LS-E12101 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIP10 / CIP4 Antibody Blocking Peptide - LS-E13812 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cip4 Partial Recombinant Protein - H00009322-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Cip4 Protein - NBP2-22864 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Cip4 Recombinant Protein - H00009322-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

TRIP10-Antibody-N-term-Blocking-Peptide - BP14358a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human Cip4 (His Tag) protein - orb179561 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect cells Species Human

TRIP10 protein (His tag) - 80R-3610 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

TRIP10 (260-545, His-tag) - AR51297PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

TRIP10 (260-545, His-tag) - AR51297PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

TRIP10 - H00009322-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRIP10 - H00009322-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRIP10 - H00009322-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIP10 - H00009322-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRIP10, 260-545aa, Human, His tag, E.coli - 01-P2477 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

TRIP10 fusion protein - Ag1251 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TRIP10, His-tagged - TRIP10-27250TH from Creative Biomart Category Protein Source E. coli

Recombinant human TRIP10, His-tagged - TRIP10-2477H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human TRIP10, GST-tagged - TRIP10-3420H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human TRIP10, His-tagged - TRIP10-405H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Human TRIP10 / Cip4 Protein (His Tag) - 14476-H08B-100 from Sino Biological Category Protein Prices $348.00, $348.00 Sizes 20 µg, 100 µg Source Baculovirus-Insect cells Species Human

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