Gene Symbol | DRAM1 |
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Entrez Gene | 55332 |
Alt Symbol | DRAM |
Species | Human |
Gene Type | protein-coding |
Description | DNA-damage regulated autophagy modulator 1 |
Other Description | DNA damage-regulated autophagy modulator protein 1|damage-regulated autophagy modulator |
Swissprots | Q8N682 Q9NUN1 B7Z4T0 Q7L3E3 |
Accessions | EAW97685 EAW97686 Q8N682 AI079438 AK002121 BAA92091 AK094923 BAG52956 AK297785 BAH12666 BC013773 AAH13773 BC018435 AAH18435 DA721965 HQ447123 ADQ31610 XM_005269004 XP_005269061 XM_005269005 XP_005269062 XM_011538536 XP_011536838 NM_018370 NP_060840 |
Function | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy. {ECO:0000269|PubMed:16839881, ECO:0000269|PubMed:17304243}. |
Subcellular Location | Lysosome membrane {ECO:0000269|PubMed:16839881}; Multi-pass membrane protein {ECO:0000269|PubMed:16839881}. |
DRAM CRISPR/Cas9 KO Plasmid (h) - sc-402399 from Santa Cruz Biotechnology
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DRAM HDR Plasmid (h) - sc-402399-HDR from Santa Cruz Biotechnology
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DRAM Double Nickase Plasmid (h) - sc-402399-NIC from Santa Cruz Biotechnology
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DRAM Double Nickase Plasmid (h2) - sc-402399-NIC-2 from Santa Cruz Biotechnology
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DRAM CRISPR Activation Plasmid (h) - sc-402399-ACT from Santa Cruz Biotechnology
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DRAM CRISPR Activation Plasmid (h2) - sc-402399-ACT-2 from Santa Cruz Biotechnology
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DRAM Lentiviral Activation Particles (h) - sc-402399-LAC from Santa Cruz Biotechnology
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DRAM Lentiviral Activation Particles (h2) - sc-402399-LAC-2 from Santa Cruz Biotechnology
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DRAM siRNA (h) - sc-96209 from Santa Cruz Biotechnology
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DRAM shRNA Plasmid (h) - sc-96209-SH from Santa Cruz Biotechnology
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DRAM shRNA (h) Lentiviral Particles - sc-96209-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU037371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7486 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7486 from Sigma-Aldrich
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DRAM1 siRNA (Human) - CRJ0664 from Cohesion Biosciences
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DRAM1 - MBS8213263 from MyBioSource
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shRNA set against Human DRAM1 (NM_018370.2) - SHH280969 from Creative biogene
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shRNA set against Human DRAM(NM_018370.2) - SHH015509 from Creative biogene
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Human DRAM1 siRNA - orb271165 from Biorbyt
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DRAM1 shRNA Plasmid (Human) - CHJ0664 from Cohesion Biosciences
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DRAM1 miRNA 3'UTR clone - MiUTR1H-02991 from Creative biogene
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