RYR2

Gene Symbol	RYR2
Entrez Gene	6262
Alt Symbol	ARVC2, ARVD2, RYR-2, RyR, VTSIP
Species	Human
Gene Type	protein-coding
Description	ryanodine receptor 2 (cardiac)
Other Description	cardiac muscle ryanodine receptor-calcium release channel|cardiac-type ryanodine receptor|islet-type ryanodine receptor|kidney-type ryanodine receptor|ryanodine receptor 2|type 2 ryanodine receptor
Swissprots	Q546N8 Q15411 Q92736 Q5T3P2
Accessions	CAC18855 CCQ43048 EAW70069 EAW70070 EAW70071 Q92736 AB204532 BAJ10285 AB204533 BAJ10286 AB204534 BAJ10287 AB204535 BAJ10288 AB204536 BAJ10289 AI218003 AJ002511 CAA05502 AK294792 BAG57915 AK297823 BAG60160 X91869 CAA62975 X98330 CAA66975 Y08218 CAA69395 XM_006711802 XP_006711865 XM_006711803 XP_006711866 XM_006711804 XP_006711867 XM_006711805 XP_006711868 XM_006711806 XP_006711869 XM_006711807 XP_006711870 XM_006711808 XP_006711871 XM_006711809 XP_006711872 XM_006711810 XP_006711873 XR_949152 NM_001035 NP_001026
Function	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:20056922}.
Subcellular Location	Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:10830164}; Multi-pass membrane protein {ECO:0000269|PubMed:10830164}. Membrane {ECO:0000305|PubMed:10830164}; Multi-pass membrane protein {ECO:0000305|PubMed:10830164}. Note=The number of predicted transmembrane domains varies between orthologs, but both N- terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.
Tissue Specificity	Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:9607712}.
Top Pathways	Dilated cardiomyopathy, Pancreatic secretion, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Circadian entrainment, Hypertrophic cardiomyopathy (HCM)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human RYR2 / Ryanodine Receptor 2 ELISA Kit (Sandwich ELISA) - LS-F5930 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.107 ng/ml Range 0.313-20 ng/ml

Human RYR2 / Ryanodine Receptor 2 ELISA Kit (Sandwich ELISA) - LS-F12527 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.313-20 ng/ml

Ryanodine Receptor 2, Cardiac (RYR2), Human, ELISA Kit - SED024Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.107ng/mL Range 0.312-20ng/mL

Ryanodine receptor 2, RYR2, Human, ELISA Kit - E1387h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

Anserine PKCq ELISA Kit - AP0112 from NeoScientific Category ELISA Kit Prices $300.00 Sizes 100 µl

Anserine PKCz ELISA Kit - AP0114 from NeoScientific Category ELISA Kit Prices $300.00 Sizes 100 µl

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS070919 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS090646 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS065572 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS085294 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.625ng/ml-20ng/ml.

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS062772 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS051276 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS058706 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS090223 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS080022 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 pg/ml. Range 31.2 pg/ml -1000 pg/ml.

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS053147 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS049822 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS073892 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS061097 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS060882 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS072920 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS102875 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS066782 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS091625 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ryanodine Receptor 2, Cardiac, ELISA Kit - MBS087029 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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