RYR2

Gene Symbol RYR2
Entrez Gene 6262
Alt Symbol ARVC2, ARVD2, RYR-2, RyR, VTSIP
Species Human
Gene Type protein-coding
Description ryanodine receptor 2 (cardiac)
Other Description cardiac muscle ryanodine receptor-calcium release channel|cardiac-type ryanodine receptor|islet-type ryanodine receptor|kidney-type ryanodine receptor|ryanodine receptor 2|type 2 ryanodine receptor
Swissprots Q546N8 Q15411 Q92736 Q5T3P2
Accessions CAC18855 CCQ43048 EAW70069 EAW70070 EAW70071 Q92736 AB204532 BAJ10285 AB204533 BAJ10286 AB204534 BAJ10287 AB204535 BAJ10288 AB204536 BAJ10289 AI218003 AJ002511 CAA05502 AK294792 BAG57915 AK297823 BAG60160 X91869 CAA62975 X98330 CAA66975 Y08218 CAA69395 XM_006711802 XP_006711865 XM_006711803 XP_006711866 XM_006711804 XP_006711867 XM_006711805 XP_006711868 XM_006711806 XP_006711869 XM_006711807 XP_006711870 XM_006711808 XP_006711871 XM_006711809 XP_006711872 XM_006711810 XP_006711873 XR_949152 NM_001035 NP_001026
Function Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:20056922}.
Subcellular Location Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:10830164}; Multi-pass membrane protein {ECO:0000269|PubMed:10830164}. Membrane {ECO:0000305|PubMed:10830164}; Multi-pass membrane protein {ECO:0000305|PubMed:10830164}. Note=The number of predicted transmembrane domains varies between orthologs, but both N- terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.
Tissue Specificity Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta. {ECO:0000269|PubMed:10830164, ECO:0000269|PubMed:9607712}.
Top Pathways Dilated cardiomyopathy, Pancreatic secretion, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Circadian entrainment, Hypertrophic cardiomyopathy (HCM)

RyR-2 CRISPR/Cas9 Knockout (KO) Plasmid (h) - sc-402986 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 HDR Plasmid (h) - sc-402986-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 HDR Plasmid (h) - sc-402986-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 Double Nickase Plasmid (h2) - sc-402986-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR CRISPR Activation Plasmid (h) - sc-402986-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 CRISPR Activation Plasmid (h2) - sc-402986-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 Lentiviral Activation Particles (h) - sc-402986-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 Lentiviral Activation Particles (h2) - sc-402986-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 siRNA (h) - sc-72012 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RyR-2 shRNA Plasmid (h) - sc-72012-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RyR-2 shRNA (h) Lentiviral Particles - sc-72012-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU063121 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1877 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1877 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RYR2 siRNA (Human) - CRH4217 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RYR2 - MBS8238461 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RYR2 (NM_001035.2) - SHH401044 from Creative biogene

Category siRNA
Species Reactivities Human

RyR-2 CRISPR/Cas9 KO Plasmid (h2) - sc-402986-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RyR-2 HDR Plasmid (h2) - sc-402986-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RYR2 shRNA Plasmid (Human) - CHH4217 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RYR2 miRNA 3'UTR clone - MiUTR1H-09100 from Creative biogene

Species Reactivities Human
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