| Gene Symbol |
KRTAP10-1
|
| Entrez Gene |
386677
|
| Alt Symbol |
KAP10.1, KAP18-1, KAP18.1, KRTAP10.1, KRTAP18-1, KRTAP18.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 10-1
|
| Other Description |
high sulfur keratin-associated protein 10.1|keratin-associated protein 10-1|keratin-associated protein 10.1|keratin-associated protein 18-1|keratin-associated protein 18.1
|
| Swissprots |
Q0VAR0 P60331 Q0VAR1
|
| Accessions |
EAX09420 P60331 AB076347 BAD01534 AJ566380 CAD97461 BC120959 AAI20960 BC120960 AAI20961 NM_198691 NP_941964
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
|