| Gene Symbol |
RAD51B
|
| Entrez Gene |
5890
|
| Alt Symbol |
R51H2, RAD51L1, REC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAD51 paralog B
|
| Other Description |
DNA repair protein RAD51 homolog 2|RAD51 homolog B|RecA-like protein|recombination repair protein
|
| Swissprots |
Q86SY3 O60914 Q86U94 Q3Y4F8 Q8N6H4 Q6FHX8 Q86SY4 Q86U92 O15315 O75210 Q86U93 Q86TR0 Q9UPL5
|
| Accessions |
AAC32425 AAC32426 AAZ85144 EAW80957 EAW80958 EAW80959 O15315 AK130466 AK309787 AK310686 AL597484 BC030219 AAH30219 BM671299 BQ101024 BX161515 CAD61950 BX248061 CAD62357 BX248766 CAD66573 CB051081 CK823089 CR536560 CAG38797 DQ890926 ABM81852 DQ894081 ABM85007 U84138 AAC39723 U92074 AAB63358 Y15571 CAA75680 XM_005267963 XP_005268020 XM_011537047 XP_011535349 XM_011537048 XP_011535350 XM_011537049 XP_011535351 XM_011537050 XP_011535352 XM_011537051 XP_011535353 XR_943503 NM_002877 NP_002868 NM_133509 NP_598193 NM_133510 NP_598194
|
| Function |
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:1175163
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in a wide range of tissues.
|
| Top Pathways |
Homologous recombination
|