RAD51B

Gene Symbol	RAD51B
Entrez Gene	5890
Alt Symbol	R51H2, RAD51L1, REC2
Species	Human
Gene Type	protein-coding
Description	RAD51 paralog B
Other Description	DNA repair protein RAD51 homolog 2|RAD51 homolog B|RecA-like protein|recombination repair protein
Swissprots	Q86SY3 O60914 Q86U94 Q3Y4F8 Q8N6H4 Q6FHX8 Q86SY4 Q86U92 O15315 O75210 Q86U93 Q86TR0 Q9UPL5
Accessions	AAC32425 AAC32426 AAZ85144 EAW80957 EAW80958 EAW80959 O15315 AK130466 AK309787 AK310686 AL597484 BC030219 AAH30219 BM671299 BQ101024 BX161515 CAD61950 BX248061 CAD62357 BX248766 CAD66573 CB051081 CK823089 CR536560 CAG38797 DQ890926 ABM81852 DQ894081 ABM85007 U84138 AAC39723 U92074 AAB63358 Y15571 CAA75680 XM_005267963 XP_005268020 XM_011537047 XP_011535349 XM_011537048 XP_011535350 XM_011537049 XP_011535351 XM_011537050 XP_011535352 XM_011537051 XP_011535353 XR_943503 NM_002877 NP_002868 NM_133509 NP_598193 NM_133510 NP_598194
Function	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:1175163
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Expressed in a wide range of tissues.
Top Pathways	Homologous recombination

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Rad51L1 full length protein - ab131933 from Abcam Category Protein Source Wheat germ Species Human

Human Rad51L1 full length protein - ab174397 from Abcam Category Protein Source E. coli Species Human

Human Rad51L1 peptide - ab99477 from Abcam Category Peptide

Human Rad51L1 peptide - ab22970 from Abcam Category Peptide Species Human

RAD51B Antibody Blocking Peptide - LS-E25443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAD51B Antibody Blocking Peptide - LS-E21083 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Rad51L1 Recombinant Protein - H00005890-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Rad51L1 Protein - NBP2-23395 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

RAD51B protein (His tag) - 80R-3598 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

RAD51L1 Blocking Peptide - 33R-4102 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RAD51L1 Peptide - AC21-0272-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RAD51L1 (1-350, His-tag) - AR51285PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RAD51L1 (1-350, His-tag) - AR51285PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RAD51L1 - H00005890-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAD51L1 - H00005890-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAD51B, 1-350aa, Human, His tag, E.coli - 01-P2465 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RAD51L1 Peptide - 46-262P from ProSci Category Peptide

RAD51L1 fusion protein - Ag4412 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RAD51L1 fusion protein - ag3884 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant human RAD51B, His-tagged - RAD51B-2465H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RAD51L1 protein, His-tagged - RAD51L1-2157H from Creative Biomart Category Protein Source E. coli Species Human

Rad51B (G226) Peptide - BS2542P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA repair protein RAD51 homolog 2(RAD51B) - CSB-YP019267HU CSB-EP019267HU CSB-BP019267HU CSB-MP019267HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAD51B, 1-350aa, Human, His tag, E.coli (Denatured) - ATGP2465 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RAD51L1 Protein - abx164881 from Abbexa Category Protein Species Human, Mouse, Rat

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