Gene Symbol | Hnf1a |
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Entrez Gene | 21405 |
Alt Symbol | AI323641, HNF1, HNF1-alpha, HNF1[a], Hnf-1, Hnf1alpha, LFB1, Tcf-1, Tcf1 |
Species | Mouse |
Gene Type | protein-coding |
Description | HNF1 homeobox A |
Other Description | HNF-1-alpha|HNF-1A|hepatocyte nuclear factor 1|hepatocyte nuclear factor 1-alpha|liver-specific transcription factor LF-B1|transcription factor 1 |
Swissprots | E9QP86 P22361 |
Accessions | AAL86441 EDL19886 P22361 AK141225 AK142644 AK142677 AK144051 BC013454 BC080698 AAH80698 M57966 AAA37821 XM_011248192 XP_011246494 NM_009327 NP_033353 |
Function | Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. {ECO:0000269|PubMed:10966642, ECO:0000269|PubMed:19289501}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Liver. |
Top Pathways | Maturity onset diabetes of the young, Signaling pathways regulating pluripotency of stem cells |
HNF-1α CRISPR/Cas9 KO Plasmid (m) - sc-423291 from Santa Cruz Biotechnology
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HNF-1α HDR Plasmid (m) - sc-423291-HDR from Santa Cruz Biotechnology
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HNF-1α Double Nickase Plasmid (m) - sc-423291-NIC from Santa Cruz Biotechnology
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HNF-1α Double Nickase Plasmid (m2) - sc-423291-NIC-2 from Santa Cruz Biotechnology
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HNF-1α CRISPR Activation Plasmid (m) - sc-423291-ACT from Santa Cruz Biotechnology
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HNF-1α CRISPR Activation Plasmid (m2) - sc-423291-ACT-2 from Santa Cruz Biotechnology
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HNF-1α Lentiviral Activation Particles (m) - sc-423291-LAC from Santa Cruz Biotechnology
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HNF-1α Lentiviral Activation Particles (m2) - sc-423291-LAC-2 from Santa Cruz Biotechnology
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HNF-1α siRNA (m) - sc-35568 from Santa Cruz Biotechnology
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HNF-1α shRNA Plasmid (m) - sc-35568-SH from Santa Cruz Biotechnology
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HNF-1α shRNA (m) Lentiviral Particles - sc-35568-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU068041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33360 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33360 from Sigma-Aldrich
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HNF1A siRNA (Mouse) - CRM4044 from Cohesion Biosciences
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HNF1A - MBS8204978 from MyBioSource
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shRNA set against Mouse Hnf1a (NM_009327.3) - SHH313621 from Creative biogene
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Mouse HNF1A siRNA - orb283520 from Biorbyt
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HNF1A shRNA Plasmid (Mouse) - CHM4044 from Cohesion Biosciences
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HNF1A miRNA 3'UTR clone - MiUTR1M-11611 from Creative biogene
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