Gene Symbol | CAD |
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Entrez Gene | 790 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
Other Description | CAD protein|CAD trifunctional protein|multifunctional protein CAD |
Swissprots | P27708 Q6P0Q0 Q96CK3 D6W552 |
Accessions | AAA51907 AAX93165 AAY24293 EAX00612 EAX00613 EAX00614 P27708 AB621827 BAK64162 AK226105 BC014178 AAH14178 BC065510 AAH65510 BG766243 BM927624 BQ447516 BU541191 BU558264 D78586 BAA11423 XM_005264555 XP_005264612 XM_005264556 XP_005264613 XM_005264557 XP_005264614 XM_005264558 XP_005264615 XM_006712101 XP_006712164 NM_001306079 NP_001293008 NM_004341 NP_004332 |
Function | This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase). {ECO:0000269|PubMed:24332717}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15890648}. Nucleus {ECO:0000269|PubMed:15890648}. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth. |
Top Pathways | Alanine, aspartate and glutamate metabolism, Pyrimidine metabolism |
CPS2 CRISPR/Cas9 KO Plasmid (h) - sc-403519 from Santa Cruz Biotechnology
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CPS2 HDR Plasmid (h) - sc-403519-HDR from Santa Cruz Biotechnology
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CPS2 Double Nickase Plasmid (h) - sc-403519-NIC from Santa Cruz Biotechnology
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CPS2 Double Nickase Plasmid (h2) - sc-403519-NIC-2 from Santa Cruz Biotechnology
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CPS2 CRISPR Activation Plasmid (h) - sc-403519-ACT from Santa Cruz Biotechnology
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CPS2 CRISPR Activation Plasmid (h2) - sc-403519-ACT-2 from Santa Cruz Biotechnology
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CPS2 Lentiviral Activation Particles (h) - sc-403519-LAC from Santa Cruz Biotechnology
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CPS2 Lentiviral Activation Particles (h2) - sc-403519-LAC-2 from Santa Cruz Biotechnology
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CPS2 siRNA (h) - sc-41457 from Santa Cruz Biotechnology
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CPS2 shRNA Plasmid (h) - sc-41457-SH from Santa Cruz Biotechnology
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CPS2 shRNA (h) Lentiviral Particles - sc-41457-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2211 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02146 from Sigma-Aldrich
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CAD siRNA (Human) - CRH0553 from Cohesion Biosciences
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CAD - MBS8224029 from MyBioSource
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shRNA set against Human CAD (NM_004341.3) - SHH253573 from Creative biogene
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shRNA set against Human CAD(NM_004341.3) - SHG132811 from Creative biogene
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CAD shRNA Plasmid (Human) - CHH0553 from Cohesion Biosciences
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CAD miRNA 3'UTR clone - MiUTR1H-01620 from Creative biogene
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