| Gene Symbol |
ASIC2
|
| Entrez Gene |
40
|
| Alt Symbol |
ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acid sensing (proton gated) ion channel 2
|
| Other Description |
acid-sensing (proton-gated) ion channel 2|acid-sensing ion channel 2|amiloride-sensitive cation channel 1, neuronal|brain sodium channel 1|mammalian degenerin homolog|neuronal amiloride-sensitive cation channel 1
|
| Swissprots |
Q16515 Q8N3E2 Q13553 Q6DJU1 E9PBX2
|
| Accessions |
CCQ43074 EAW80216 Q16515 AK127748 BAG54565 AK313043 BAG35875 AL834182 CAD38879 BC075042 AAH75042 BC075043 AAH75043 EU446513 ABZ92042 U50352 AAC50432 U53212 AAC50498 U57352 AAB49182 NM_001094 NP_001085 NM_183377 NP_899233
|
| Function |
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}.
|
| Tissue Specificity |
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:8631835}.
|
| Top Pathways |
Taste transduction, Inflammatory mediator regulation of TRP channels
|
![Western Blot: ACCN1 Overexpression Lysate (Adult Normal) [NBL1-07230] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ACCN1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5518_ACCN1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07230-img0002.jpg)