ASIC2
| Gene Symbol | ASIC2 |
|---|---|
| Entrez Gene | 40 |
| Alt Symbol | ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acid sensing (proton gated) ion channel 2 |
| Other Description | acid-sensing (proton-gated) ion channel 2|acid-sensing ion channel 2|amiloride-sensitive cation channel 1, neuronal|brain sodium channel 1|mammalian degenerin homolog|neuronal amiloride-sensitive cation channel 1 |
| Swissprots | Q16515 Q8N3E2 Q13553 Q6DJU1 E9PBX2 |
| Accessions | CCQ43074 EAW80216 Q16515 AK127748 BAG54565 AK313043 BAG35875 AL834182 CAD38879 BC075042 AAH75042 BC075043 AAH75043 EU446513 ABZ92042 U50352 AAC50432 U53212 AAC50498 U57352 AAB49182 NM_001094 NP_001085 NM_183377 NP_899233 |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}. |
| Tissue Specificity | Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:8631835}. |
| Top Pathways | Taste transduction, Inflammatory mediator regulation of TRP channels |
ASIC2 CRISPR/Cas9 KO Plasmid (h) - sc-403265 from Santa Cruz Biotechnology
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ASIC2 HDR Plasmid (h) - sc-403265-HDR from Santa Cruz Biotechnology
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ASIC2 Double Nickase Plasmid (h) - sc-403265-NIC from Santa Cruz Biotechnology
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ASIC2 Double Nickase Plasmid (h2) - sc-403265-NIC-2 from Santa Cruz Biotechnology
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ASIC2 CRISPR Activation Plasmid (h) - sc-403265-ACT from Santa Cruz Biotechnology
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ASIC2 CRISPR Activation Plasmid (h2) - sc-403265-ACT-2 from Santa Cruz Biotechnology
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ASIC2 Lentiviral Activation Particles (h) - sc-403265-LAC from Santa Cruz Biotechnology
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ASIC2 Lentiviral Activation Particles (h2) - sc-403265-LAC-2 from Santa Cruz Biotechnology
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ASIC2 siRNA (h) - sc-42409 from Santa Cruz Biotechnology
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ASIC2 shRNA Plasmid (h) - sc-42409-SH from Santa Cruz Biotechnology
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ASIC2 shRNA (h) Lentiviral Particles - sc-42409-V from Santa Cruz Biotechnology
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ACCN1 RNAi - H00000040-R02 from Novus Biologicals
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MISSION® esiRNA - EHU065621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2707 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2707 from Sigma-Aldrich
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ASIC2 siRNA (Human) - CRH0032 from Cohesion Biosciences
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ACCN1 RNAi - H00000040-R01 from Novus Biologicals
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ASIC2 - MBS829905 from MyBioSource
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ASIC2 CRISPR/Cas9 KO Plasmid (h2) - sc-403265-KO-2 from Santa Cruz Biotechnology
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ASIC2 HDR Plasmid (h2) - sc-403265-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ACCN1 (NM_001094.4) - SHH230110 from Creative biogene
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shRNA set against Human ACCN1(NM_001094.4) - SHG029071 from Creative biogene
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shRNA set against Human ACCN1(NM_183377.1) - SHG029107 from Creative biogene
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Human ASIC2 siRNA - orb260534 from Biorbyt
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ASIC2 shRNA Plasmid (Human) - CHH0032 from Cohesion Biosciences
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