KCNJ13
| Gene Symbol | KCNJ13 |
|---|---|
| Entrez Gene | 3769 |
| Alt Symbol | KIR1.4, KIR7.1, LCA16, SVD |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, inwardly rectifying subfamily J, member 13 |
| Other Description | inward rectifier K(+) channel Kir7.1|inward rectifier potassium channel 13|potassium inwardly-rectifying channel, subfamily J, member 13 |
| Swissprots | Q53SA1 Q8N3Y4 O76023 A0PGH1 O60928 |
| Accessions | AAD08673 AAX93190 EAW71019 O60928 AF061118 AAC15769 AJ006128 CAA06878 AJ007557 CAA07552 AK314019 BAG36730 AY758240 AAX08098 AY758241 AAX08099 BC037290 AAH37290 CB410257 DA278958 DB173405 DB547266 DN993097 DQ891724 ABM82650 DQ894901 ABM85827 NM_001172416 NP_001165887 NM_001172417 NP_001165888 NM_002242 NP_002233 |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord. |
| Top Pathways | Protein digestion and absorption |
KIR7.1 CRISPR/Cas9 KO Plasmid (h) - sc-403910 from Santa Cruz Biotechnology
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KIR7.1 HDR Plasmid (h) - sc-403910-HDR from Santa Cruz Biotechnology
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KIR7.1 Double Nickase Plasmid (h) - sc-403910-NIC from Santa Cruz Biotechnology
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KIR7.1 Double Nickase Plasmid (h2) - sc-403910-NIC-2 from Santa Cruz Biotechnology
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KIR7.1 CRISPR Activation Plasmid (h) - sc-403910-ACT from Santa Cruz Biotechnology
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KIR7.1 CRISPR Activation Plasmid (h2) - sc-403910-ACT-2 from Santa Cruz Biotechnology
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KIR7.1 Lentiviral Activation Particles (h) - sc-403910-LAC from Santa Cruz Biotechnology
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KIR7.1 Lentiviral Activation Particles (h2) - sc-403910-LAC-2 from Santa Cruz Biotechnology
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KIR7.1 siRNA (h) - sc-42630 from Santa Cruz Biotechnology
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KIR7.1 shRNA Plasmid (h) - sc-42630-SH from Santa Cruz Biotechnology
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KIR7.1 shRNA (h) Lentiviral Particles - sc-42630-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2070 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2070 from Sigma-Aldrich
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KCNJ13 siRNA (Human) - CRH2545 from Cohesion Biosciences
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KCNJ13 RNAi - H00003769-R01 from Novus Biologicals
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KCNJ13, siRNA - MBS8202287 from MyBioSource
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KCNJ13, siRNA - MBS8230490 from MyBioSource
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KCNJ13, siRNA - MBS827309 from MyBioSource
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Human KCNJ13 siRNA - orb263047 from Biorbyt
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KCNJ13 shRNA Plasmid (Human) - CHH2545 from Cohesion Biosciences
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