Gene Symbol | LIN9 |
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Entrez Gene | 286826 |
Alt Symbol | BARA, BARPsv, Lin-9, TGS, TGS1, TGS2 |
Species | Human |
Gene Type | protein-coding |
Description | lin-9 DREAM MuvB core complex component |
Other Description | TUDOR gene similar protein|beta subunit-associated regulator of apoptosis|lin-9 homolog|pRB-associated protein|protein lin-9 homolog|rb related pathway actor|type I interferon receptor beta chain-associated protein |
Swissprots | Q5U7E1 Q7Z3J1 Q6PI55 Q5U5L8 Q6ZTV4 Q5TKA1 |
Accessions | EAW69780 EAW69781 EAW69782 Q5TKA1 AF190323 AAQ13710 AF190324 AAQ13711 AK125690 AK126177 BAC86475 AK308823 AY166858 AAN87840 AY166859 AAN87841 AY786184 AAV41873 BC043444 AAH43444 BC045625 AAH45625 BC065302 AAH65302 BX537869 CAD97871 XM_005273102 XP_005273159 XM_006711766 XP_006711829 XM_006711767 XP_006711830 XM_011544173 XP_011542475 XR_949138 NM_001270409 NP_001257338 NM_001270410 NP_001257339 NM_173083 NP_775106 |
Function | Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. |
Subcellular Location | Nucleus, nucleoplasm {ECO:0000269|PubMed:15538385, ECO:0000269|PubMed:16730350}. Note=Found in perinucleolar structures. Associated with chromatin. |
Tissue Specificity | Expressed in thymus and testis. {ECO:0000269|PubMed:15538385}. |
LIN-9 CRISPR/Cas9 KO Plasmid (h) - sc-418584 from Santa Cruz Biotechnology
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LIN-9 HDR Plasmid (h) - sc-418584-HDR from Santa Cruz Biotechnology
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LIN-9 Double Nickase Plasmid (h) - sc-418584-NIC from Santa Cruz Biotechnology
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LIN-9 Double Nickase Plasmid (h2) - sc-418584-NIC-2 from Santa Cruz Biotechnology
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LIN-9 CRISPR Activation Plasmid (h) - sc-418584-ACT from Santa Cruz Biotechnology
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LIN-9 CRISPR Activation Plasmid (h2) - sc-418584-ACT-2 from Santa Cruz Biotechnology
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LIN-9 Lentiviral Activation Particles (h) - sc-418584-LAC from Santa Cruz Biotechnology
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LIN-9 Lentiviral Activation Particles (h2) - sc-418584-LAC-2 from Santa Cruz Biotechnology
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LIN-9 siRNA (h) - sc-88786 from Santa Cruz Biotechnology
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LIN-9 shRNA Plasmid (h) - sc-88786-SH from Santa Cruz Biotechnology
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LIN-9 shRNA (h) Lentiviral Particles - sc-88786-V from Santa Cruz Biotechnology
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LIN9 RNAi - H00286826-R02 from Novus Biologicals
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MISSION® esiRNA - EHU158091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11736 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11736 from Sigma-Aldrich
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LIN9 siRNA (Human) - CRJ7181 from Cohesion Biosciences
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shRNA set against Human LIN9 (NM_173083.3) - SHH330563 from Creative biogene
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LIN9 shRNA Plasmid (Human) - CHJ7181 from Cohesion Biosciences
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LIN9 miRNA 3'UTR clone - MiUTR3H-10569 from Creative biogene
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