| Gene Symbol |
SRR
|
| Entrez Gene |
63826
|
| Alt Symbol |
ILV1, ISO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine racemase
|
| Other Description |
D-serine ammonia-lyase|D-serine dehydratase|L-serine ammonia-lyase|L-serine dehydratase
|
| Swissprots |
Q6IA55 D3DTI5 Q9GZT4
|
| Accessions |
CAC69570 CAE90864 CAY04175 CBF95504 CBV09024 EAW90553 EAW90554 EAW90555 Q9GZT4 AF169974 AAG27081 AI952697 AK023169 BAB14442 AK223120 BAD96840 AL834378 CAD39041 AY034081 AAK58495 AY743705 AAW66460 AY743706 AAW66461 AY743707 AAW66462 AY743708 AAW66463 BC057234 BC074728 AAH74728 CR457300 CAG33581 DA297969 XM_006721565 XP_006721628 XM_006721566 XP_006721629 XM_011523974 XP_011522276 XM_011523975 XP_011522277 NM_001304803 NP_001291732 NM_021947 NP_068766
|
| Function |
Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269|PubMed:11054547, ECO:0000269|PubMed:20106978}.
|
| Tissue Specificity |
Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:15193426}.
|
| Top Pathways |
Glycine, serine and threonine metabolism
|