SRR

Gene Symbol SRR
Entrez Gene 63826
Alt Symbol ILV1, ISO1
Species Human
Gene Type protein-coding
Description serine racemase
Other Description D-serine ammonia-lyase|D-serine dehydratase|L-serine ammonia-lyase|L-serine dehydratase
Swissprots Q6IA55 D3DTI5 Q9GZT4
Accessions CAC69570 CAE90864 CAY04175 CBF95504 CBV09024 EAW90553 EAW90554 EAW90555 Q9GZT4 AF169974 AAG27081 AI952697 AK023169 BAB14442 AK223120 BAD96840 AL834378 CAD39041 AY034081 AAK58495 AY743705 AAW66460 AY743706 AAW66461 AY743707 AAW66462 AY743708 AAW66463 BC057234 BC074728 AAH74728 CR457300 CAG33581 DA297969 XM_006721565 XP_006721628 XM_006721566 XP_006721629 XM_011523974 XP_011522276 XM_011523975 XP_011522277 NM_001304803 NP_001291732 NM_021947 NP_068766
Function Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269|PubMed:11054547, ECO:0000269|PubMed:20106978}.
Tissue Specificity Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:15193426}.
Top Pathways Glycine, serine and threonine metabolism

Serine racemase (A-4) - sc-365217 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Serine racemase (A-4): sc-365217. Western blot analysis of Serine racemase expression in HEK293 whole cell lysate (A) and mouse brain tissue extract (B).

Serine racemase (H-150) - sc-48741 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Serine racemase (H-150): sc-48741. Western blot analysis of Serine racemase expression in mouse brain tissue extract.

Serine racemase (T-16) - sc-5752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Serine racemase (A-17): sc-5752. Western blot analysis of Serine racemase expression in rat brain (A) and mouse brain (B) tissue extracts.

Serine racemase (A-17) - sc-5751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Serine racemase (A-17): sc-5751. Western blot analysis of Serine racemase expression in mouse brain tissue extract.

Anti-Serine racemase antibody - ab45434 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab45434 stained human SHSY5Y cells. The cells were methanol fixed (5 min), permabilised in 0.1% PBS-Tween (20 min) and incubated with the antibody (ab45434, 5µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red).  DAPI was used to stain the cell nuclei (blue). However, this Fast-Track antibody is not yet fully characterised.  This image represents inconclusive preliminary data.

Anti-Serine racemase antibody - ab45545 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab45545 stained human SHSY5Y cells. The cells were methanol fixed (10 min), permabilised in 0.1% PBS-Tween (20 min) and incubated with the antibody (ab45545, 5µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue). 

Anti-Serine racemase antibody [402CT2.1.2] - ab61335 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 402CT2.1.2
Anti-Serine racemase antibody [402CT2.1.2] (ab61335) at 5 µg/ml + Mouse Hippocampus Tissue Lysate at 20 µgSecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutionPerformed under reducing conditions.

Anti-Serine racemase antibody [7E8] - ab123894 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7E8
All lanes : Anti-Serine racemase antibody [7E8] (ab123894) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY Serine racemase cDNALysates/proteins at 5 µg per lane.

Anti-Serine racemase antibody [EPR16682] - ab200833 from Abcam

Prices $99.00, $347.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16682
All lanes : Anti-Serine racemase antibody [EPR16682] (ab200833) at 1/5000 dilutionLane 1 : LNCaP (Human prostate cancer cell line) whole cell lysateLane 2 : Human fetal brain lysateLane 3 : U-87 MG (Human glioblastoma-astrocytoma epithelial cell line) whole cell lysateLane 4 : HEK293 (Human embryonic kidney) whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1000

Anti-SRR / Serine Racemase Antibody (clone 5D10) - LS-C114998 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D10
IHC of paraffin-embedded prostate tissue using anti-SRR mouse monoclonal antibody. (Dilution 1:50).

Anti-SRR / Serine Racemase Antibody (clone 1D7) - LS-C114999 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D7
IHC of paraffin-embedded Carcinoma of bladder tissue using anti-SRR mouse monoclonal antibody. (Dilution 1:50).

Anti-SRR / Serine Racemase Antibody (aa131-340) IHC-plus™ - LS-B11864 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-SRR / Serine Racemase Antibody (clone 2E3) - LS-C114997 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E3
IHC of paraffin-embedded Carcinoma of thyroid tissue using anti-SRR mouse monoclonal antibody. (Dilution 1:50).

Anti-SRR / Serine Racemase Antibody (clone 9E8) IHC-plus™ - LS-B10209 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 9E8
Anti-SRR / Serine Racemase antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10209 concentration 10 ug/ml.

Anti-SRR / Serine Racemase Antibody (aa1-180) - LS-C311901 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRR / Serine Racemase Antibody (aa1-140) - LS-C311899 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Serine racemase antibody used in Western blot.

Anti-SRR / Serine Racemase Antibody (C-Terminus) - LS-C116694 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRR / Serine Racemase antibody LS-C116694 Western blot of HCT15 cell lysate.

Anti-SRR / Serine Racemase Antibody (clone 7G6) - LS-C115012 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7G6
Anti-SRR mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SRR.

Anti-SRR / Serine Racemase Antibody (clone 7B6) - LS-C115000 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B6
IHC of paraffin-embedded Kidney tissue using anti-SRR mouse monoclonal antibody. (Dilution 1:50).

Anti-SRR / Serine Racemase Antibody (clone 5G3) - LS-C115031 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G3
IHC of paraffin-embedded Kidney tissue using anti-SRR mouse monoclonal antibody. (Dilution 1:50).

Serine racemase Antibody (2E3) - NBP2-02332 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E3
Western Blot: Serine racemase Antibody (2E3) [NBP2-02332] - HEK293T cells were transfected with the pCMV6- ENTRY control (Left lane) or pCMV6-ENTRY SRR (RC210359, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with antiSRR.

Serine racemase Antibody - H00063826-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Serine racemase Antibody [H00063826-B01] - analysis of SRR expression in transfected 293T cell line by SRR MaxPab polyclonal antibody (B01). Lane 1: SRR transfected lysate (36.60 KDa). Lane 2: Non-transfected lysate.

Serine racemase Antibody - H00063826-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Rabbit Anti-Serine racemase Polyclonal Antibody - bs-11673R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-Serine racemase Polyclonal Antibody, Unconjugated (bs-11673R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
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