CYP4F8

Gene Symbol CYP4F8
Entrez Gene 11283
Alt Symbol CPF8, CYPIVF8
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily F, polypeptide 8
Other Description cytochrome P450 4F8|cytochrome P450, subfamily IVF, polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase
Swissprots P98187
Accessions EAW84486 EAW84487 P98187 AF133298 AAD49566 AI401776 AK092612 AK096809 AK300478 BAG62194 AK300530 BAG62241 AK300539 BAG62247 AK314685 BAG37237 BC146322 AAI46323 BC156576 AAI56577 DA871128 DA877298 DB329701 XM_011527653 XP_011525955 XM_011527654 XP_011525956 NM_007253 NP_009184
Function Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin. {ECO:0000269|PubMed:10791960, ECO:0000269|PubMed:15789615, ECO:0000269|PubMed:16112640}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}.
Tissue Specificity Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions. {ECO:0000269|PubMed:10405341, ECO:0000269|PubMed:12464258, ECO:0000269|PubMed:15789615}.
Top Pathways Arachidonic acid metabolism

CYP4F8 (T-17) - sc-246396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CYP4F8 (L-12) - sc-246397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CYPIVF8 antibody - ab80107 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CYPIVF8 antibody (ab80107) at 1/50 dilution + K562 cell line lysates at 35 µg

Anti-CYPIVF8 antibody - ab168565 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CYPIVF8 antibody (ab168565) at 1 µg/mlLane 1 : CYPIVF8 transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-CYP4F8 Antibody (Internal) - LS-C346008 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CP4F8 Antibody with human 786-0 Whole Cell lysate.

Anti-CYP4F8 Antibody (C-Terminus) - LS-C99444 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of anti-CYP4F8 Antibody in K562 cell line lysates (35 ug/lane). CYP4F8(arrow) was detected using the purified antibody.

CYPIVF8 Antibody - H00011283-B01P-50ug from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CYP4F8 antibody produced in mouse - SAB1412805 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
<B>Immunoblotting</B><BR/>Anti-CYP4F8:<B>Cat. No. SAB1412805</B>: Antibody concentration: 0.1–5 μg/mL. Immunofluorescence band of ~57.2 kDa using CYP4F8 transfected 293T lysate.<BR/><B>Lane</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CYP4F8 (C-term) antibody produced in rabbit - SAB1300951 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP4F8 (C-term) Antibody: <B>Cat. No. SAB1300951</B>: CYP4F8 in K562 cell line lysates with Anti-CYP4F8 (C-term) Antibody at 4.0 μg/mL.

ANTI-CYP4F8(C-TERMINAL) antibody produced in rabbit - SAB1305349 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP4F8 (C-term): <B>Cat. No. SAB1305349</B>: Western blot analysis of Anti-CYP4F8 (C-term)in K562 cell line lysates (35 μg/lane).

CP4F8 Antibody - middle region (ARP60829_P050) - ARP60829_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CYP4F8-Antibody-C-term - AP7890b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of anti-CYP4F8 Antibody (C-term)(Cat.#AP7890b) in K562 cell line lysates (35ug/lane). CYP4F8(arrow) was detected using the purified Pab.

CYP4F8 Antibody - C-terminal region (OAAB04969) - OAAB04969 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CYP4F8 antibody, C-term - GTX81247 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-CYP4F8 antibody, C-term used in Western blot. GTX81247

CYPIVF8 antibody (FITC) - orb187173 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

CYP4F8 antibody - 20011-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal

CYP4F8 (C-term) antibody - AP14742PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of anti-CYP4F8 Antibody (C-term) in K562 cell line lysates (35ug/lane). CYP4F8(arrow) was detected using the purified Pab.

CYP4F8 antibody - H00011283-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

CYP4F8 antibody - 20011-1-AP from Proteintech Group

Prices $279.00
Sizes con: 34 μg/150μl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human skin tissue slide using 20011-1-AP( CYP4F8 Antibody) at dilution of 1:50 (under 10x lens)

CYP4F8 Antibody - EPP12104 from Elabscience

Prices $296.00, $485.00
Sizes 120 μl, 200 μl
Host Rabbit
Clonality Polyclonal

Anti-CYP4F8 (full length) polyclonal antibody - DPABH-07257 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

Anti-CYP4F8 monoclonal antibody - DCABH-11203 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

CYP4F8 Polyclonal Antibody - PA5-15057 from Thermo Fisher Scientific

Prices $349.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis using a CYP4F8 polyclonal antibody (Product # PA5-15057) in K562 cell lysates (35ug per lane).

CYP4F8, Polyclonal Antibody - MBS624933 from MyBioSource

Prices $550.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

CYP4F8, Polyclonal Antibody - MBS2525607 from MyBioSource

Prices $195.00, $270.00, $435.00
Sizes 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal
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