| Gene Symbol |
CYP4F8
|
| Entrez Gene |
11283
|
| Alt Symbol |
CPF8, CYPIVF8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 4, subfamily F, polypeptide 8
|
| Other Description |
cytochrome P450 4F8|cytochrome P450, subfamily IVF, polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase
|
| Swissprots |
P98187
|
| Accessions |
EAW84486 EAW84487 P98187 AF133298 AAD49566 AI401776 AK092612 AK096809 AK300478 BAG62194 AK300530 BAG62241 AK300539 BAG62247 AK314685 BAG37237 BC146322 AAI46323 BC156576 AAI56577 DA871128 DA877298 DB329701 XM_011527653 XP_011525955 XM_011527654 XP_011525956 NM_007253 NP_009184
|
| Function |
Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin. {ECO:0000269|PubMed:10791960, ECO:0000269|PubMed:15789615, ECO:0000269|PubMed:16112640}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions. {ECO:0000269|PubMed:10405341, ECO:0000269|PubMed:12464258, ECO:0000269|PubMed:15789615}.
|
| Top Pathways |
Arachidonic acid metabolism
|
