ATP8A2

Gene Symbol ATP8A2
Entrez Gene 51761
Alt Symbol ATP, ATPIB, CAMRQ4, IB, ML-1
Species Human
Gene Type protein-coding
Description ATPase, aminophospholipid transporter, class I, type 8A, member 2
Other Description ATPase class I type 8A member 2|ATPase, aminophospholipid transporter-like, class I, type 8A, member 2|P4-ATPase flippase complex alpha subunit ATP8A2|phospholipid-transporting ATPase IB|probable phospholipid-transporting ATPase IB
Swissprots Q9NTL2 Q9NTI2 Q9NPU6 Q9NYM3 Q9H527
Accessions CAE84542 EAX08372 EAX08373 EAX08374 EAX08375 EAX08376 Q9NTI2 AF236871 AAF40215 AK022096 AK094653 BAC04396 AK126031 BAC86402 AK127263 BAC86905 AK302980 BAH13866 AK310254 AL137256 CAB70658 AL390129 CAB99084 BC144228 BC144229 BC156471 AAI56472 BC172535 AAI72535 BX537836 CAD97848 XM_005266419 XP_005266476 XM_011535103 XP_011533405 XM_011535104 XP_011533406 XM_011535105 XP_011533407 XM_011535106 XP_011533408 XM_011535107 XP_011533409 XM_011535108 XP_011533410 XM_011535109 XP_011533411 XM_011535110 XP_011533412 XM_011535111 XP_011533413 XM_011535112 XP_011533414 XM_011535113 XP_011533415 XM_011535114 XP_011533416 XM_011535115 XP_011533417 NM_016529 NP_057613
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:20947505}. Endosome {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:20947505}. Note=Localizes to the Golgi and endosomes in photoreceptor cells. Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity). {ECO:0000250}.
Tissue Specificity Strongly expressed in the brain, cerebellum, retina and testis. {ECO:0000269|PubMed:20683487, ECO:0000269|PubMed:22892528}.

ATP8A2 (H-45) - sc-292155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ATP8A2 (H-45): sc-292155. Western blot analysis of ATP8A2 expression in K-562 (A) and T98G (B) whole cell lysates.

ATP8A2 (N-19) - sc-83990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

ATP8A2 (S-14) - sc-83991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 antibody - ab107188 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ATP8A2 antibody (ab107188) at 1/100 dilution + K562 cell line lysates at 35 µg

Anti-ATP8A2 Antibody (aa296-326, APC) - LS-C212861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326, AP) - LS-C212862 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326, Biotin) - LS-C212863 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326, FITC) - LS-C212864 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326, Azide-free, HRP) - LS-C212865 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326) - LS-C319711 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326, PE) - LS-C212866 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 Antibody (aa296-326) - LS-C156675 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ATP8A2 Antibody western blot of K562 cell line lysates (35 ug/lane). The ATP8A2 antibody detected the ATP8A2 protein (arrow).

ATP8A2 Antibody - NBP1-88899 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: ATP8A2 Antibody [NBP1-88899] - Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

ANTI-ATP8A2 (N-TERM) antibody produced in rabbit - SAB1303810 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATP8A2 antibody produced in rabbit - HPA039926 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ATP8A2: <B>Cat. No. HPA039926</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

ATP8A2 Antibody - N-terminal region (OAAB00955) - OAAB00955 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

ATP8A2-Antibody-N-term - AP10934a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
ATP8A2 Antibody (N-term) (Cat. #AP10934a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ATP8A2 antibody detected the ATP8A2 protein (arrow).

ABCA4 antibody, C-term - GTX88710 from GeneTex

Prices $289.00
Sizes 100 μg
Host Goat
Clonality Polyclonal
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