ATP8A2

Gene Symbol	ATP8A2
Entrez Gene	51761
Alt Symbol	ATP, ATPIB, CAMRQ4, IB, ML-1
Species	Human
Gene Type	protein-coding
Description	ATPase, aminophospholipid transporter, class I, type 8A, member 2
Other Description	ATPase class I type 8A member 2|ATPase, aminophospholipid transporter-like, class I, type 8A, member 2|P4-ATPase flippase complex alpha subunit ATP8A2|phospholipid-transporting ATPase IB|probable phospholipid-transporting ATPase IB
Swissprots	Q9NTL2 Q9NTI2 Q9NPU6 Q9NYM3 Q9H527
Accessions	CAE84542 EAX08372 EAX08373 EAX08374 EAX08375 EAX08376 Q9NTI2 AF236871 AAF40215 AK022096 AK094653 BAC04396 AK126031 BAC86402 AK127263 BAC86905 AK302980 BAH13866 AK310254 AL137256 CAB70658 AL390129 CAB99084 BC144228 BC144229 BC156471 AAI56472 BC172535 AAI72535 BX537836 CAD97848 XM_005266419 XP_005266476 XM_011535103 XP_011533405 XM_011535104 XP_011533406 XM_011535105 XP_011533407 XM_011535106 XP_011533408 XM_011535107 XP_011533409 XM_011535108 XP_011533410 XM_011535109 XP_011533411 XM_011535110 XP_011533412 XM_011535111 XP_011533413 XM_011535112 XP_011533414 XM_011535113 XP_011533415 XM_011535114 XP_011533416 XM_011535115 XP_011533417 NM_016529 NP_057613
Function	Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:20947505}. Endosome {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:20947505}. Note=Localizes to the Golgi and endosomes in photoreceptor cells. Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity). {ECO:0000250}.
Tissue Specificity	Strongly expressed in the brain, cerebellum, retina and testis. {ECO:0000269|PubMed:20683487, ECO:0000269|PubMed:22892528}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ATP8A2 CRISPR/Cas9 KO Plasmid (h) - sc-408886 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 HDR Plasmid (h) - sc-408886-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 Double Nickase Plasmid (h) - sc-408886-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 Double Nickase Plasmid (h2) - sc-408886-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 CRISPR Activation Plasmid (h) - sc-408886-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 CRISPR Activation Plasmid (h2) - sc-408886-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 Lentiviral Activation Particles (h) - sc-408886-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 Lentiviral Activation Particles (h2) - sc-408886-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ATP8A2 siRNA (h) - sc-105108 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATP8A2 shRNA Plasmid (h) - sc-105108-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ATP8A2 shRNA (h) Lentiviral Particles - sc-105108-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU065681 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3742 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3742 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08801 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08801

ATP8A2 siRNA (Human) - CRH9938 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ATP8A2 RNAi - H00051761-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ATP8A2 - MBS8226395 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ATP8A2 (NM_016529.4) - SHH243286 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ATP8A2(NM_016529.4) - SHG084565 from Creative biogene Category siRNA Species Reactivities Human

ATP8A2 shRNA Plasmid (Human) - CHH9938 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ATP8A2 miRNA 3'UTR clone - MiUTR1H-00728 from Creative biogene Species Reactivities Human

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