| Gene Symbol | GRIA4 |
|---|---|
| Entrez Gene | 2893 |
| Alt Symbol | GLUR4, GLUR4C, GLURD, GluA4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, AMPA 4 |
| Other Description | AMPA-selective glutamate receptor 4|gluR-4|gluR-D|glutamate receptor 4|glutamate receptor, ionotrophic, AMPA 4 |
| Swissprots | P48058 Q86XE8 |
| Accessions | EAW67066 EAW67067 EAW67068 EAW67069 P48058 AB115416 BAD23796 AB209092 BAD92329 AK311193 BC015199 BC035610 BC045546 AAH45546 BC114549 AAI14550 BC142654 AAI42655 BC146816 AAI46817 BC150209 AAI50210 BC167786 AAI67786 BM675457 BM723114 DA077870 DA391203 DB298333 DB305322 DB473702 DB548729 FJ947075 ACR45952 FJ947076 ACR45953 JN547407 AEQ93811 U16129 AAA95962 XM_005271518 XP_005271575 XM_006718823 XP_006718886 XM_011542775 XP_011541077 XM_011542776 XP_011541078 XM_011542777 XP_011541079 XR_947825 NM_000829 NP_000820 NM_001077243 NP_001070711 NM_001077244 NP_001070712 NM_001112812 NP_001106283 NR_046356 |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:21172611}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. {ECO:0000250}. |
| Top Pathways | Glutamatergic synapse, Dopaminergic synapse, Amphetamine addiction, Nicotine addiction, Retrograde endocannabinoid signaling |