| Gene Symbol | CD38 |
|---|---|
| Entrez Gene | 952 |
| Alt Symbol | ADPRC 1, T10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD38 molecule |
| Other Description | 2'-phospho-ADP-ribosyl cyclase|2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase|2'-phospho-cyclic-ADP-ribose transferase|ADP-ribosyl cyclase 1|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1|CD38 antigen (p45)|NAD(+) nucleosidase|cADPr hydrolase 1|cyclic ADP-ribose hydrolase 1 |
| Swissprots | P28907 Q96HY4 O00122 O00121 |
| Accessions | AAY99634 BAA18966 CDM22270 EAW92745 EAW92746 P28907 AA417096 AK297592 BAG59979 AK303169 BAG64268 AK313268 BAG36077 BC007964 AAH07964 CD688069 D84276 BAA18964 D84277 BAA18965 DQ893184 ABM84110 EU176777 ABW03578 M34461 AAA68482 XR_241678 NM_001775 NP_001766 |
| Function | Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
| Subcellular Location | Membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269|PubMed:9074508}. |
| Top Pathways | Hematopoietic cell lineage, Calcium signaling pathway, Salivary secretion, Pancreatic secretion, Epstein-Barr virus infection |