Gene Symbol | CD38 |
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Entrez Gene | 952 |
Alt Symbol | ADPRC 1, T10 |
Species | Human |
Gene Type | protein-coding |
Description | CD38 molecule |
Other Description | 2'-phospho-ADP-ribosyl cyclase|2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase|2'-phospho-cyclic-ADP-ribose transferase|ADP-ribosyl cyclase 1|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1|CD38 antigen (p45)|NAD(+) nucleosidase|cADPr hydrolase 1|cyclic ADP-ribose hydrolase 1 |
Swissprots | P28907 Q96HY4 O00122 O00121 |
Accessions | AAY99634 BAA18966 CDM22270 EAW92745 EAW92746 P28907 AA417096 AK297592 BAG59979 AK303169 BAG64268 AK313268 BAG36077 BC007964 AAH07964 CD688069 D84276 BAA18964 D84277 BAA18965 DQ893184 ABM84110 EU176777 ABW03578 M34461 AAA68482 XR_241678 NM_001775 NP_001766 |
Function | Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Tissue Specificity | Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. {ECO:0000269|PubMed:9074508}. |
Top Pathways | Hematopoietic cell lineage, Calcium signaling pathway, Salivary secretion, Pancreatic secretion, Epstein-Barr virus infection |
CD38 CRISPR/Cas9 KO Plasmid (h) - sc-401117 from Santa Cruz Biotechnology
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CD38 HDR Plasmid (h) - sc-401117-HDR from Santa Cruz Biotechnology
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CD38 Double Nickase Plasmid (h) - sc-401117-NIC from Santa Cruz Biotechnology
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CD38 Double Nickase Plasmid (h2) - sc-401117-NIC-2 from Santa Cruz Biotechnology
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CD38 CRISPR Activation Plasmid (h) - sc-401117-ACT from Santa Cruz Biotechnology
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CD38 CRISPR Activation Plasmid (h2) - sc-401117-ACT-2 from Santa Cruz Biotechnology
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CD38 Lentiviral Activation Particles (h) - sc-401117-LAC from Santa Cruz Biotechnology
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CD38 Lentiviral Activation Particles (h2) - sc-401117-LAC-2 from Santa Cruz Biotechnology
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CD38 siRNA (h) - sc-29996 from Santa Cruz Biotechnology
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CD38 shRNA Plasmid (h) - sc-29996-SH from Santa Cruz Biotechnology
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CD38 shRNA (h) Lentiviral Particles - sc-29996-V from Santa Cruz Biotechnology
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CD38 RNAi - H00000952-R02 from Novus Biologicals
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MISSION® esiRNA - EHU053231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5725 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5725 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1122 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04464 from Sigma-Aldrich
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CD38 siRNA (Human) - CRH0674 from Cohesion Biosciences
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CD38 - MBS8225763 from MyBioSource
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shRNA set against Human CD38 (NM_001775.2) - SHH259033 from Creative biogene
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shRNA set against Human CD38(NM_001775.2) - SHG157039 from Creative biogene
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CD38 CRISPR/Cas9 KO Plasmid (h2) - sc-401117-KO-2 from Santa Cruz Biotechnology
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CD38 HDR Plasmid (h2) - sc-401117-HDR-2 from Santa Cruz Biotechnology
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Human CD38 siRNA - orb261176 from Biorbyt
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CD38 shRNA Plasmid (Human) - CHH0674 from Cohesion Biosciences
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