| Gene Symbol |
KDM4D
|
| Entrez Gene |
55693
|
| Alt Symbol |
JMJD2D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 4D
|
| Other Description |
jmjC domain-containing histone demethylation protein 3D|jumonji domain containing 2D|jumonji domain-containing protein 2D|lysine-specific demethylase 4D
|
| Swissprots |
Q9NT41 Q6B0I6 Q9NW76 Q0VF39 B3KPC4
|
| Accessions |
EAW66952 Q6B0I6 AK001113 BAA91508 AK056162 BAG51636 AL137545 CAB70803 AW593120 BC031862 BC074739 AAH74739 BC119010 AAI19011 BC122858 AAI22859 CA311555 NM_018039 NP_060509
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}.
|