Gene Symbol | KDM4D |
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Entrez Gene | 55693 |
Alt Symbol | JMJD2D |
Species | Human |
Gene Type | protein-coding |
Description | lysine (K)-specific demethylase 4D |
Other Description | jmjC domain-containing histone demethylation protein 3D|jumonji domain containing 2D|jumonji domain-containing protein 2D|lysine-specific demethylase 4D |
Swissprots | Q9NT41 Q6B0I6 Q9NW76 Q0VF39 B3KPC4 |
Accessions | EAW66952 Q6B0I6 AK001113 BAA91508 AK056162 BAG51636 AL137545 CAB70803 AW593120 BC031862 BC074739 AAH74739 BC119010 AAI19011 BC122858 AAI22859 CA311555 NM_018039 NP_060509 |
Function | Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00537}. |
JMJD2D CRISPR/Cas9 KO Plasmid (h) - sc-404743 from Santa Cruz Biotechnology
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JMJD2D HDR Plasmid (h) - sc-404743-HDR from Santa Cruz Biotechnology
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JMJD2D Double Nickase Plasmid (h) - sc-404743-NIC from Santa Cruz Biotechnology
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JMJD2D Double Nickase Plasmid (h2) - sc-404743-NIC-2 from Santa Cruz Biotechnology
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JMJD2D CRISPR Activation Plasmid (h) - sc-404743-ACT from Santa Cruz Biotechnology
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JMJD2D CRISPR Activation Plasmid (h2) - sc-404743-ACT-2 from Santa Cruz Biotechnology
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JMJD2D Lentiviral Activation Particles (h) - sc-404743-LAC from Santa Cruz Biotechnology
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JMJD2D Lentiviral Activation Particles (h2) - sc-404743-LAC-2 from Santa Cruz Biotechnology
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JMJD2D siRNA (h) - sc-96274 from Santa Cruz Biotechnology
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JMJD2D shRNA Plasmid (h) - sc-96274-SH from Santa Cruz Biotechnology
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JMJD2D shRNA (h) Lentiviral Particles - sc-96274-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU014031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11033 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11033 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05161 from Sigma-Aldrich
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KDM4D siRNA (Human) - CRJ0838 from Cohesion Biosciences
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shRNA set against Human KDM4D (NM_018039.2) - SHH324223 from Creative biogene
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Human KDM4D siRNA - orb271339 from Biorbyt
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KDM4D shRNA Plasmid (Human) - CHJ0838 from Cohesion Biosciences
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KDM4D miRNA 3'UTR clone - MiUTR1H-05069 from Creative biogene
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