| Gene Symbol |
MAN1B1
|
| Entrez Gene |
11253
|
| Alt Symbol |
ERMAN1, MANA-ER, MRT15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mannosidase, alpha, class 1B, member 1
|
| Other Description |
ER alpha 1,2-mannosidase|Man9GlcNAc2-specific processing alpha-mannosidase|endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase|endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1
|
| Swissprots |
Q9Y5K7 Q9BRS9 Q5VSG3 Q9UKM7
|
| Accessions |
EAW88345 EAW88346 EAW88347 Q9UKM7 AB209276 BAD92513 AF145732 AAD45504 AF148509 AAF03215 AI312031 AK074559 BAC11060 AK074699 BAG51987 AK094878 AK126926 AK127005 AK128033 AK128257 BAG54653 AK128341 BAG54664 AK130143 AK298480 BAG60691 AK299043 BAG61117 AK309808 AK315797 AL110221 CAB53680 AY358465 AAQ88830 BC002953 AAH02953 BC006079 AAH06079 BE731944 BM848429 BQ448144 CR749534 CAH18340 DA763005 DQ891861 ABM82787 DQ895050 ABM85976 XM_006716945 XP_006717008 NM_016219 NP_057303 NR_045720 NR_045721
|
| Function |
Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269|PubMed:12090241, ECO:0000269|PubMed:18003979}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:10409699}; Single-pass type II membrane protein {ECO:0000269|PubMed:10409699}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10409699, ECO:0000269|PubMed:10521544}.
|
| Top Pathways |
N-Glycan biosynthesis, Protein processing in endoplasmic reticulum
|