Gene Symbol | CACNG2 |
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Entrez Gene | 10369 |
Alt Symbol | MRD10 |
Species | Human |
Gene Type | protein-coding |
Description | calcium channel, voltage-dependent, gamma subunit 2 |
Other Description | TARP gamma-2|neuronal voltage-gated calcium channel gamma-2 subunit|stargazin|transmembrane AMPAR regulatory protein gamma-2|voltage-dependent calcium channel gamma-2 subunit |
Swissprots | Q9Y698 Q5TGT3 Q9UGZ7 Q2M1M1 |
Accessions | EAW60113 Q9Y698 AF096322 AAD22738 AK123431 BC069612 AAH69612 BC112297 AAI12298 BC112299 AAI12300 BE670632 BI919073 CR456414 CAG30300 CU012974 CAK54405 CU013262 CAK54704 HG512270 HQ258186 ADR82940 NM_006078 NP_006069 |
Function | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:20805473}. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Brain. |
Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
L-type Ca ++ CP γ2 CRISPR/Cas9 KO Plasmid (h) - sc-411463 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 HDR Plasmid (h) - sc-411463-HDR from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 Double Nickase Plasmid (h) - sc-411463-NIC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 Double Nickase Plasmid (h2) - sc-411463-NIC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 CRISPR Activation Plasmid (h) - sc-411463-ACT from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 CRISPR Activation Plasmid (h2) - sc-411463-ACT-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 Lentiviral Activation Particles (h) - sc-411463-LAC from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 Lentiviral Activation Particles (h2) - sc-411463-LAC-2 from Santa Cruz Biotechnology
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L-type Ca ++ CP γ2 siRNA (h) - sc-42696 from Santa Cruz Biotechnology
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L-type C ++ CP γ2 shRNA Plasmid (h) - sc-42696-SH from Santa Cruz Biotechnology
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L-type C ++ CP γ2 shRNA (h) Lentiviral Particles - sc-42696-V from Santa Cruz Biotechnology
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Stargazin RNAi - H00010369-R01 from Novus Biologicals
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MISSION® esiRNA - EHU042601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5274 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5274 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02491 from Sigma-Aldrich
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CACNG2 siRNA (Human) - CRH7026 from Cohesion Biosciences
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CACNG2 - MBS8223515 from MyBioSource
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shRNA set against Human CACNG2 (NM_006078.3) - SHH253477 from Creative biogene
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Human CACNG2 siRNA - orb267528 from Biorbyt
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CACNG2 shRNA Plasmid (Human) - CHH7026 from Cohesion Biosciences
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CACNG2 miRNA 3'UTR clone - MiUTR3H-05402 from Creative biogene
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