OAS1

Gene Symbol OAS1
Entrez Gene 4938
Alt Symbol IFI-4, OIAS, OIASI
Species Human
Gene Type protein-coding
Description 2'-5'-oligoadenylate synthetase 1, 40/46kDa
Other Description (2-5')oligo(A) synthase 1|(2-5')oligo(A) synthetase 1|2',5'-oligo A synthetase 1|2',5'-oligoadenylate synthetase 1, 40/46kDa|2'-5' oligoadenylate synthetase 1 p48 isoform|2'-5' oligoadenylate synthetase 1 p52 isoform|2'-5'-oligoadenylate synthase 1|2'-5'-oligoisoadenylate synthetase 1|2-5A synthase 1|2-5A synthetase 1|E18/E16|p46/p42 OAS
Swissprots P29080 Q1PG42 P78485 Q16701 Q53GC5 P04820 P78486 Q6IPC6 Q6A1Z3 Q6P7N9 Q96J61 A8K4N8 P00973 P29081 Q16700 Q53YA4 Q3ZM01
Accessions AAA59955 AAB59552 AAB59553 ABE27977 ABE27978 CAA01166 CAA01167 CAA29803 CAA30164 CBX53842 CBX53843 CBX53844 EAW98019 EAW98020 EAW98021 EAW98022 EAW98023 P00973 AJ629455 CAF33358 AK123528 AK223006 BAD96726 AK225384 AK291003 BAF83692 AK300346 BAG62090 AK301498 BAG63009 AY730627 AAW63049 AY730628 AAW63050 BC000562 AAH00562 BC061587 AAH61587 BC071981 AAH71981 BE048946 BF055326 BT006785 AAP35431 CB112445 D00068 BAA00047 DQ823040 ABH07381 DQ891892 ABM82818 DQ895079 ABM86005 DQ914956 ABI78946 X02661 CAA26497 X02874 CAA26633 X02875 CAA26634 X04371 CAB51602 XM_006719434 XP_006719497 XM_011538413 XP_011536715 XM_011538414 XP_011536716 XR_944557 XR_944558 NM_001032409 NP_001027581 NM_002534 NP_002525 NM_016816 NP_058132
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19923450}. Mitochondrion {ECO:0000269|PubMed:19923450}. Nucleus {ECO:0000269|PubMed:19923450}. Microsome {ECO:0000269|PubMed:19923450}. Endoplasmic reticulum {ECO:0000269|PubMed:19923450}. Secreted {ECO:0000250}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
Top Pathways Hepatitis C, Measles, Influenza A, Herpes simplex infection

OAS1 (F-3) - sc-374656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OAS1 (F-3): sc-374656. Western blot analysis of OAS1 expression in non-transfected (A) and human OAS1 transfected (B) whole cell lysates.

OAS1 (A-17) - sc-49833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OAS1 (A-17): sc-49833. Western blot analysis of OAS1 expression in Caco-2 whole cell lysate.

OAS1 (H-90) - sc-98424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OAS1 (H-90): sc-98424. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic and nuclear staining of glandular cells.

OAS1 (V-18) - sc-49849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OAS1 (V-18): sc-49849. Western blot analysis of OAS1 expression in non-transfected: sc-110760 (A) and human OAS1 transfected (B) 293 whole cell lysates.

OAS1 (18-K) - sc-100639 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
OAS1 (18-K): sc-100639. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon tissue showing nuclear localization.

Oas1a/g (R-50) - sc-98426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Oas1a/g (R-50): sc-98426. Western blot analysis of Oas1a/g expression in BC<sub>3</sub>H1 (A), NIH/3T3 (B), EOC 20 (C) and Neuro-2A (D) whole cell lysates.

Anti-OAS1 antibody - ab86343 from Abcam

Prices $382.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-OAS1 antibody (ab86343) at 1 µg/ml (in 5% skim milk / PBS buffer) + transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-OAS1 antibody - ab55771 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
OAS1 antibody (ab55771) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-OAS1 antibody - ab82666 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab82666 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab82666, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-OAS1 antibody - ab99024 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 antibody - C-terminal - ab186894 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-OAS1 antibody - C-terminal (ab186894) at 1 µg/ml + HepG2 whole cell lysate at 10 µg

Anti-OAS1 Antibody (aa309-339, AP) - LS-C264908 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa309-339, APC) - LS-C264909 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa309-339, Biotin) - LS-C264910 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa309-339, FITC) - LS-C264911 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa309-339, Azide-free, HRP) - LS-C264912 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa309-339, PE) - LS-C264915 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa370-382) - LS-C205044 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
OAS1 antibody (1 ug/ml) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-OAS1 Antibody (aa347-396) - LS-C206137 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
OAS1 antibody Western Blot of HepG2. Antibody dilution: 1 ug/ml.

Anti-OAS1 Antibody (aa74-165, Biotin) - LS-C300175 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa302-330) - LS-C100473 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with OAS1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-OAS1 Antibody (aa74-165, FITC) - LS-C303291 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa1-215) - LS-C178938 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody (aa309-339) - LS-C323510 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-OAS1 Antibody - LS-C341751 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more