| Gene Symbol | OAS1 |
|---|---|
| Entrez Gene | 4938 |
| Alt Symbol | IFI-4, OIAS, OIASI |
| Species | Human |
| Gene Type | protein-coding |
| Description | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| Other Description | (2-5')oligo(A) synthase 1|(2-5')oligo(A) synthetase 1|2',5'-oligo A synthetase 1|2',5'-oligoadenylate synthetase 1, 40/46kDa|2'-5' oligoadenylate synthetase 1 p48 isoform|2'-5' oligoadenylate synthetase 1 p52 isoform|2'-5'-oligoadenylate synthase 1|2'-5'-oligoisoadenylate synthetase 1|2-5A synthase 1|2-5A synthetase 1|E18/E16|p46/p42 OAS |
| Swissprots | P29080 Q1PG42 P78485 Q16701 Q53GC5 P04820 P78486 Q6IPC6 Q6A1Z3 Q6P7N9 Q96J61 A8K4N8 P00973 P29081 Q16700 Q53YA4 Q3ZM01 |
| Accessions | AAA59955 AAB59552 AAB59553 ABE27977 ABE27978 CAA01166 CAA01167 CAA29803 CAA30164 CBX53842 CBX53843 CBX53844 EAW98019 EAW98020 EAW98021 EAW98022 EAW98023 P00973 AJ629455 CAF33358 AK123528 AK223006 BAD96726 AK225384 AK291003 BAF83692 AK300346 BAG62090 AK301498 BAG63009 AY730627 AAW63049 AY730628 AAW63050 BC000562 AAH00562 BC061587 AAH61587 BC071981 AAH71981 BE048946 BF055326 BT006785 AAP35431 CB112445 D00068 BAA00047 DQ823040 ABH07381 DQ891892 ABM82818 DQ895079 ABM86005 DQ914956 ABI78946 X02661 CAA26497 X02874 CAA26633 X02875 CAA26634 X04371 CAB51602 XM_006719434 XP_006719497 XM_011538413 XP_011536715 XM_011538414 XP_011536716 XR_944557 XR_944558 NM_001032409 NP_001027581 NM_002534 NP_002525 NM_016816 NP_058132 |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. {ECO:0000269 |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19923450}. Mitochondrion {ECO:0000269|PubMed:19923450}. Nucleus {ECO:0000269|PubMed:19923450}. Microsome {ECO:0000269|PubMed:19923450}. Endoplasmic reticulum {ECO:0000269|PubMed:19923450}. Secreted {ECO:0000250}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. |
| Top Pathways | Hepatitis C, Measles, Influenza A, Herpes simplex infection |