ADRB2

Gene Symbol ADRB2
Entrez Gene 154
Alt Symbol ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Species Human
Gene Type protein-coding
Description adrenoceptor beta 2, surface
Other Description adrenergic, beta-2-, receptor, surface|adrenoceptor beta 2 surface|beta-2 adrenergic receptor|beta-2 adrenoceptor|beta-2 adrenoreceptor|catecholamine receptor
Swissprots Q9UCZ3 Q6P4D8 Q9UH95 Q8NEQ9 P07550 Q53GA6 Q9UMZ5 Q9UCZ1 Q4JG18 Q96EC3 B0LPE4 O14826 Q9UHA1 Q9UCZ0 Q6GMT4 O14825 O14823 O14824 B2R7X2 Q9UCZ2
Accessions AAA88017 AAB82148 AAB82149 AAB82150 AAB82151 AAD48036 AAF17569 AAF20199 AAG35451 AAY88739 ABY87523 CAA68289 CBJ06537 EAW61798 P07550 AA886615 AK223025 BAD96745 AK313151 BAG35969 AY136741 AAN01267 BC012481 AAH12481 BC063486 AAH63486 BC073856 AAH73856 DA705141 KJ534762 AHW56402 M15169 AAA88014 X04827 CAA28511 NM_000024 NP_000015
Function Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19584355}; Multi-pass membrane protein {ECO:0000269|PubMed:19584355}. Note=Colocalizes with VHL at the cell membrane.
Top Pathways Calcium signaling pathway, Endocytosis, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway

β2-Adrenergic Receptor (D6H2) Rabbit mAb - 8513 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6H2
Western blot analysis of ACHN cells or 293T cells, either mock transfected (-) or transfected (+) with a cDNA expression construct encoding human β2-adrenergic receptor (hβ2AR), using β2-Adrenergic Receptor (D6H2) Rabbit mAb.

β 2 -AR (H-20) - sc-569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
β<sub>2</sub>-AR (H-20): sc-569. Western blot analysis of β<sub>2</sub>-AR expression in non-transfected: sc-117752 (A) and human β<sub>2</sub>-AR transfected: sc-113753 (B) 293T whole cell lysates.

β 2 -AR (H-73) - sc-9042 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
β<sub>2</sub>-AR (H-73): sc-9042. Western blot analysis of β<sub>2</sub>-AR expression in A-431 (A) and IMR-32 (B) nuclear extracts.

β 2 -AR (M-20) - sc-570 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
β<sub>2</sub>-AR (M-20): sc-570. Western blot analysis of β<sub>2</sub>-AR expression in non-transfected: sc-117752 (A) and human β<sub>2</sub>-AR transfected: sc-112395 (B) 293T whole cell lysates.

β 2 -AR (R11E1) - sc-81577 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
β<sub>2</sub>-AR (R11E1): sc-81577. Western blot analysis of β<sub>2</sub>-AR expression in non-transfected: sc-117752 (A) and human β<sub>2</sub>-AR transfected: sc-112395 (B) 293T whole cell lysates.

β 2 -AR (I3D6) - sc-81578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
β<sub>2</sub>-AR (I3D6): sc-81578. Western blot analysis of β<sub>2</sub>-AR expression in non-transfected: sc-117752 (A) and human β<sub>2</sub>-AR transfected: sc-112395 (B) 293T whole cell lysates.

p-β 2 -AR (Ser 345/Ser 346) - sc-16718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-β 2 -AR (Tyr 350) - sc-16720 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-β<sub>2</sub>-AR (Tyr 350)-R: sc-16720-R. Western blot analysis of β<sub>2</sub>-AR phosphorylation in untreated (A), PMA treated (B) and PMA and lambda protein phosphatase treated (C) HeLa whole cell lysates.

p-β 2 -AR (Tyr 141) - sc-17275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-β<sub>2</sub>-AR (Tyr 141)-R: sc-17275-R. Western blot analysis of β<sub>2</sub>-AR phosphorylation in PMA treated (A) and PMA and lambda protein phosphatase treated (B) HeLa whole cell lysates.

Anti-beta 2 Adrenergic Receptor (phospho S346) antibody - ab62464 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62464, at 1/50 dilution, staining beta 2 Adrenergic Receptor in paraffin-embedded human brain tissue by Immunohistochemistry in the absence or presence of the immunising peptide.

Anti-beta 2 Adrenergic Receptor (phospho S346) antibody - ab195724 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta 2 Adrenergic Receptor (phospho S346) antibody (ab195724) at 1/500 dilutionLane 1 : Nocodazole treated HepG2 whole cell lysates with Antigen-specific peptide.Lane 2 : Nocodazole treated HepG2 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-beta 2 Adrenergic Receptor (phospho Y346) antibody - ab192821 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta 2 Adrenergic Receptor (phospho Y346) antibody (ab192821) at 1/500 dilutionLane 1 : HepG2 cell extractsLane 2 : HepG2 cell extracts treated with Nocodazole.

Anti-beta 2 Adrenergic Receptor antibody - ab61778 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61778, at 1/50 - 1/100 dilution, staining beta 2 Adrenergic Receptor in paraffin-embedded human brain tissue by immunohistochemistry, in the absence (left panel) or presence (right panel) of the immunising peptide.

Anti-beta 2 Adrenergic Receptor antibody - ab13989 from Abcam

Prices $388.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-beta 2 Adrenergic Receptor antibody - ab176490 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-beta 2 Adrenergic Receptor antibody (ab176490) at 2.5 µg/ml + Rat heart membrane extract at 20 µg

Anti-beta 2 Adrenergic Receptor antibody - ab135641 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-beta 2 Adrenergic Receptor antibody (ab135641) at 1/50 dilution + Mouse kidney lysate at 35 µg

Anti-beta 2 Adrenergic Receptor antibody - ab40834 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-beta 2 Adrenergic Receptor antibody (ab40834) at 0.2 µg/ml + Human Liver lysate at 35 µg

Anti-beta 2 Adrenergic Receptor antibody - ab107217 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
All lanes : Anti-beta 2 Adrenergic Receptor antibody (ab107217) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Brain (Mouse) Tissue LysateLane 3 : Brain (Rat) Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal Secondary Antibody to Chicken IgY - H&L (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-beta 2 Adrenergic Receptor antibody - ab69598 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta 2 Adrenergic Receptor antibody (ab69598) at 1/500 dilutionLane 1 : Extracts from HeLa cellsLane 2 : Extracts from HeLa cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-beta 2 Adrenergic Receptor antibody [6H8] - ab125150 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6H8
Overlay histogram showing SHSY-5Y cells stained with ab125150 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab125150, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive result in 4% paraformaldehyde (10 min) fixed SHSY-5Y cells used under the same conditions. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-beta 2 Adrenergic Receptor antibody [EPR707(N)] - ab182136 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR707(N)
Western blot analysis of immunoprecipitation pellet from HeLa cell lysate (+) or a negative control (-) immunoprecipitated using ab182136 at 1/30 dilution.Secondary: Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1500 dilution.

Anti-beta 2 Adrenergic Receptor antibody - Aminoterminal end - ab71219 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-beta 2 Adrenergic Receptor antibody - Aminoterminal end (ab71219) at 1/440 dilution + HL60 cell line lysates at 35 µg

Anti-beta 2 Adrenergic Receptor antibody - C-terminal - ab137494 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab137494 stained PC3 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab137494 at 1µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ADRB2 Antibody - LS-C96195 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADRB2 Antibody (aa335-408) - LS-C63768 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
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