| Gene Symbol |
ANP32A
|
| Entrez Gene |
8125
|
| Alt Symbol |
C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
|
| Other Description |
acidic leucine-rich nuclear phosphoprotein 32 family member A|acidic nuclear phosphoprotein pp32|cerebellar leucine rich acidic nuclear protein|hepatopoietin Cn|inhibitor-1 of protein phosphatase-2A|leucine-rich acidic nuclear protein|mapmodulin|potent heat-stable protein phosphatase 2A inhibitor I1PP2A|putative HLA-DR-associated protein I|putative human HLA class II associated protein I
|
| Swissprots |
Q5J8L8 B2R6T4 Q7M4N6 Q53FK4 P39687
|
| Accessions |
EAW77824 EAW77825 P39687 AF025684 AAB91548 AK127498 AK223280 BAD97000 AK312703 BAG35581 AW383928 AY007110 AY349171 AAQ79832 BC000608 AAH00608 BC007200 AAH07200 BC064969 BC106719 AAI06720 BC125143 AAI25144 BT007436 AAP36104 DA825897 DQ893294 ABM84220 DQ896729 ABM87728 U60823 AAC50570 U73477 AAB39706 X75090 CAA52981 XM_006720707 XP_006720770 NM_006305 NP_006296
|
| Function |
Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:17557114}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala. {ECO:0000269|PubMed:15642345}.
|
