| Gene Symbol |
CELF5
|
| Entrez Gene |
60680
|
| Alt Symbol |
BRUNOL-5, BRUNOL5, CELF-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CUGBP, Elav-like family member 5
|
| Other Description |
CUG-BP and ETR-3 like factor 5|CUGBP Elav-like family member 5|RNA-binding protein BRUNOL-5|bruno-like 5 RNA binding protein
|
| Swissprots |
Q9NR86 O75253 Q59GP2 D6W614 Q8N6W0 Q86VW6 Q9BZC0
|
| Accessions |
AAC27666 EAW69327 EAW69328 Q8N6W0 AA448420 AB209067 BAD92304 AF248649 AAF86231 AF329266 AAK07476 AK294109 BAG57444 AL832550 BC028101 AAH28101 BC047522 DQ891648 ABM82574 DQ894837 ABM85763 XM_006722832 XP_006722895 XM_006722833 XP_006722896 XM_006722834 XP_006722897 XM_006722836 XP_006722899 XM_006722837 XP_006722900 XM_006722838 XP_006722901 XM_011528173 XP_011526475 XM_011528174 XP_011526476 XM_011528175 XP_011526477 XR_430147 XR_430148 NM_001172673 NP_001166144 NM_021938 NP_068757 NR_033342
|
| Function |
RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain. {ECO:0000269|PubMed:11158314}.
|
![Western Blot: BRUNOL5 Overexpression Lysate (Adult Normal) [NBP2-06501] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BRUNOL5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6111_BRUNOL5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06501-img0001.jpg)