Gene Symbol | CELF5 |
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Entrez Gene | 60680 |
Alt Symbol | BRUNOL-5, BRUNOL5, CELF-5 |
Species | Human |
Gene Type | protein-coding |
Description | CUGBP, Elav-like family member 5 |
Other Description | CUG-BP and ETR-3 like factor 5|CUGBP Elav-like family member 5|RNA-binding protein BRUNOL-5|bruno-like 5 RNA binding protein |
Swissprots | Q9NR86 O75253 Q59GP2 D6W614 Q8N6W0 Q86VW6 Q9BZC0 |
Accessions | AAC27666 EAW69327 EAW69328 Q8N6W0 AA448420 AB209067 BAD92304 AF248649 AAF86231 AF329266 AAK07476 AK294109 BAG57444 AL832550 BC028101 AAH28101 BC047522 DQ891648 ABM82574 DQ894837 ABM85763 XM_006722832 XP_006722895 XM_006722833 XP_006722896 XM_006722834 XP_006722897 XM_006722836 XP_006722899 XM_006722837 XP_006722900 XM_006722838 XP_006722901 XM_011528173 XP_011526475 XM_011528174 XP_011526476 XM_011528175 XP_011526477 XR_430147 XR_430148 NM_001172673 NP_001166144 NM_021938 NP_068757 NR_033342 |
Function | RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed in brain. {ECO:0000269|PubMed:11158314}. |
CELF5 CRISPR/Cas9 KO Plasmid (h) - sc-409313 from Santa Cruz Biotechnology
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CELF5 HDR Plasmid (h) - sc-409313-HDR from Santa Cruz Biotechnology
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CELF5 Double Nickase Plasmid (h) - sc-409313-NIC from Santa Cruz Biotechnology
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CELF5 Double Nickase Plasmid (h2) - sc-409313-NIC-2 from Santa Cruz Biotechnology
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CELF5 CRISPR Activation Plasmid (h) - sc-409313-ACT from Santa Cruz Biotechnology
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CELF5 CRISPR Activation Plasmid (h2) - sc-409313-ACT-2 from Santa Cruz Biotechnology
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CELF5 Lentiviral Activation Particles (h) - sc-409313-LAC from Santa Cruz Biotechnology
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CELF5 Lentiviral Activation Particles (h2) - sc-409313-LAC-2 from Santa Cruz Biotechnology
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CELF5 siRNA (h) - sc-97170 from Santa Cruz Biotechnology
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CELF5 shRNA Plasmid (h) - sc-97170-SH from Santa Cruz Biotechnology
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CELF5 shRNA (h) Lentiviral Particles - sc-97170-V from Santa Cruz Biotechnology
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BRUNOL5 RNAi - H00060680-R01 from Novus Biologicals
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MISSION® esiRNA - EHU146561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5929 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5929 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02167 from Sigma-Aldrich
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CELF5 siRNA (Human) - CRJ1829 from Cohesion Biosciences
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CELF5 - MBS8226176 from MyBioSource
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shRNA set against Human CELF5 (NM_021938.3) - SHH261509 from Creative biogene
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shRNA set against Human BRUNOL5(NM_021938.3) - SHG105649 from Creative biogene
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CELF5 shRNA Plasmid (Human) - CHJ1829 from Cohesion Biosciences
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CELF5 miRNA 3'UTR clone - MiUTR1H-00955 from Creative biogene
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