Gene Symbol | RFXANK |
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Entrez Gene | 8625 |
Alt Symbol | ANKRA1, BLS, F14150_1, RFX-B |
Species | Human |
Gene Type | protein-coding |
Description | regulatory factor X-associated ankyrin-containing protein |
Other Description | DNA-binding protein RFXANK|RFX-Bdelta4|ankyrin repeat family A protein 1|ankyrin repeat-containing regulatory factor X-associated protein|regulatory factor X subunit B |
Swissprots | Q24JQ1 O95839 Q6FGA8 O14593 |
Accessions | AAB86654 CAC09014 CDL97006 CDL97007 EAW84795 EAW84796 EAW84797 EAW84798 EAW84799 O14593 AF077196 AAD26991 AF094760 AAC69883 AF105427 AAD17972 AF105428 AAD17973 AW411190 AW411361 BC114558 AAI14559 BC114563 AAI14564 BG740813 BM682278 BM712354 CR456981 CAG33262 CR542199 CAG46996 CX871218 X75690 XM_005260134 XP_005260191 XM_005260135 XP_005260192 XM_005260136 XP_005260193 XM_005260137 XP_005260194 XM_006722930 XP_006722993 NM_001278727 NP_001265656 NM_001278728 NP_001265657 NM_003721 NP_003712 NM_134440 NP_604389 |
Function | Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes. |
Subcellular Location | Nucleus. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Primary immunodeficiency, Tuberculosis, Antigen processing and presentation |
RFX-B CRISPR/Cas9 KO Plasmid (h) - sc-410552 from Santa Cruz Biotechnology
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RFX-B HDR Plasmid (h) - sc-410552-HDR from Santa Cruz Biotechnology
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RFX-B Double Nickase Plasmid (h) - sc-410552-NIC from Santa Cruz Biotechnology
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RFX-B Double Nickase Plasmid (h2) - sc-410552-NIC-2 from Santa Cruz Biotechnology
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RFX-B CRISPR Activation Plasmid (h) - sc-410552-ACT from Santa Cruz Biotechnology
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RFX-B CRISPR Activation Plasmid (h2) - sc-410552-ACT-2 from Santa Cruz Biotechnology
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RFX-B Lentiviral Activation Particles (h) - sc-410552-LAC from Santa Cruz Biotechnology
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RFX-B Lentiviral Activation Particles (h2) - sc-410552-LAC-2 from Santa Cruz Biotechnology
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RFX-B siRNA (h) - sc-37751 from Santa Cruz Biotechnology
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RFX-B shRNA Plasmid (h) - sc-37751-SH from Santa Cruz Biotechnology
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RFX-B shRNA (h) Lentiviral Particles - sc-37751-V from Santa Cruz Biotechnology
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RFXANK RNAi - H00008625-R01 from Novus Biologicals
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RFXANK RNAi - H00008625-R02 from Novus Biologicals
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MISSION® esiRNA - EHU065301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18192 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18192 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00532 from Sigma-Aldrich
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RFXANK siRNA (Human) - CRH5668 from Cohesion Biosciences
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RFXANK - MBS8225418 from MyBioSource
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shRNA set against Human RFXANK (NM_003721.2) - SHH392480 from Creative biogene
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shRNA set against Human RFXANK(NM_003721.2) - SHR169870 from Creative biogene
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shRNA set against Human RFXANK(NM_134440.1) - SHR169950 from Creative biogene
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RFXANK shRNA Plasmid (Human) - CHH5668 from Cohesion Biosciences
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RFXANK miRNA 3'UTR clone - MiUTR1H-08765 from Creative biogene
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RFXANK miRNA 3'UTR clone - MiUTR1H-08766 from Creative biogene
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