XIAP

Gene Symbol	XIAP
Entrez Gene	331
Alt Symbol	API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species	Human
Gene Type	protein-coding
Description	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3
Swissprots	D3DTF2 P98170 Q9NQ14
Accessions	AAW62257 CAW32364 CAW32374 EAX11858 EAX11859 EAX11860 EAX11861 P98170 AK130423 AK309704 AK313883 BAG36609 BC030771 BC032729 AAH32729 BQ423165 DA316362 DQ890857 ABM81783 DQ894012 ABM84938 H09548 U32974 AAC50518 XM_006724754 XP_006724817 XM_011531329 XP_011529631 NM_001167 NP_001158 NM_001204401 NP_001191330 NR_037916
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can
Subcellular Location	Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
Tissue Specificity	Ubiquitous, except peripheral blood leukocytes.
Top Pathways	Apoptosis, Ubiquitin mediated proteolysis, Focal adhesion, Small cell lung cancer, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

XIAP-Over-expression-Lysate - LY11559a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

BIRC4 293T Cell Transient Overexpression Lysate(Denatured) - H00000331-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

BIRC4 HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L148T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

XIAP 293 Cell Lysate - 409409 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

XIAP Overexpression Lysate (Denatured) - H00000331-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

XIAP Overexpression Lysate (Native) - NBL1-17905 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

XIAP (h): 293T Lysate - sc-115280 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

XIAP Over-expression Lysate Product - GWB-F0BDB0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

XIAP knockout Cell lysate - LC810597 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human XIAP Knockdown Stable Cell Line - CSC-DC017567 from Creative biogene Category Cell Line Species Human

Human XIAP Knockout Cell Line-HeLa - CSC-RT0710 from Creative biogene Category Cell Line Species Human

XIAP KO Cell Lysate-HeLa - CLKO-0215 from Creative biogene Category Cell Lysate

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