XIAP

Gene Symbol XIAP
Entrez Gene 331
Alt Symbol API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species Human
Gene Type protein-coding
Description X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3
Swissprots D3DTF2 P98170 Q9NQ14
Accessions AAW62257 CAW32364 CAW32374 EAX11858 EAX11859 EAX11860 EAX11861 P98170 AK130423 AK309704 AK313883 BAG36609 BC030771 BC032729 AAH32729 BQ423165 DA316362 DQ890857 ABM81783 DQ894012 ABM84938 H09548 U32974 AAC50518 XM_006724754 XP_006724817 XM_011531329 XP_011529631 NM_001167 NP_001158 NM_001204401 NP_001191330 NR_037916
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can
Subcellular Location Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
Tissue Specificity Ubiquitous, except peripheral blood leukocytes.
Top Pathways Apoptosis, Ubiquitin mediated proteolysis, Focal adhesion, Small cell lung cancer, Toxoplasmosis

XIAP (D2Z8W) Rabbit mAb - 14334 from Cell Signaling Technology

Prices $250.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2Z8W
Western blot analysis of extracts from various cell lines using XIAP (D2Z8W) Rabbit mAb.

XIAP (3B6) Rabbit mAb - 2045 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 3B6
Western blot analysis of extracts from HeLa, Raji and COS cell lines, using XIAP (3B6) Rabbit mAb.

XIAP Antibody - 2042 from Cell Signaling Technology

Prices $99.00, $246.00, $596.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa (human), C6 (rat) and BaF3 (mouse) cell lines, using XIAP Antibody.

XIAP (N-18) - sc-8789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XIAP (N-18): sc-8789. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

XIAP (H-202) - sc-11426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
XIAP (H-202): sc-11426. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

XIAP (D-2) - sc-55552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XIAP (D-2): sc-55552. Western blot analysis of XIAP expression in HeLa whole cell lysate (A) and mouse thymus (B) and rat kidney (C) tissue extracts.

XIAP (E-2) - sc-55551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XIAP (E-2): sc-55551. Western blot analysis of XIAP expression in HeLa whole cell lysate (A) and mouse thymus (B) and rat kidney (C) tissue extracts.

XIAP (C-14) - sc-8790 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XIAP (C-14): sc-8790. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

XIAP (A-7) - sc-55550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XIAP (A-7): sc-55550. Western blot analysis of XIAP expression in HeLa whole cell lysate (A) and mouse thymus (B) and rat kidney (C) tissue extracts.

Anti-XIAP (phospho S87) antibody - ab193315 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XIAP (phospho S87) antibody (ab193315) at 1/500 dilutionLane 1 : HepG2 cell extract treated with anisomycinLane 2 : HepG2 cell extract treated with anisomycin with antigen-specific peptide

Anti-XIAP (phospho S87) antibody [EPR572(N)] - ab175935 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR572(N)
All lanes : Anti-XIAP (phospho S87) antibody [EPR572(N)] (ab175935) at 1/1000 dilutionLane 1 : Hela cell lysateLane 2 : Hela cell lysate treated with Okadaic acid and Calyculin ALysates/proteins at 10 µg per lane.

Anti-XIAP antibody - ab21278 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-XIAP antibody (ab21278) at 0.5 µg/mlLane 2 : Anti-XIAP antibody (ab21278) at 1 µg/mlLane 3 : Anti-XIAP antibody (ab21278) at 2 µg/mlLane 1 : Human kidney lysate Lane 2 : Human kidney lysate Lane 3 : Human kidney lysate

Anti-XIAP antibody - ab2541 from Abcam

Prices $390.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab2541 (1/200) staining XIAP in HeLa cells (green). Cells were permeabilised with 0.5% Triton-X100/ PBS, fixed in methanol (-20oC, 10min) and counterstained with DAPI (red) in order to highlight the nucleus. Please refer to abreview for further experimental details.See Abreview

Anti-XIAP antibody - ab113089 from Abcam

Prices $384.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab113089 at 10 &microg/ml staining XIAP in Formalin-fixed, Paraffin-embedded Human pancreas tissue by Immunohistochemistry.

Anti-XIAP antibody - ab137392 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-XIAP antibody (ab137392) at 1/1000 dilution + NIH 3T3 whole cell lysate at 30 µg

Anti-XIAP antibody - ab54788 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Standard curve of recombinant tagged XIAP using ab54788 as capture antibody

Anti-XIAP antibody - ab59282 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue using ab59282 at a dilution of 1/50. Left hand image - without immunizing peptide; right hand image - with immunizing peptide.

Anti-XIAP antibody - ab97685 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Anti-HIF-1-alpha antibody [H1alpha67] - ChIP Grade (ab1) at 1/500 dilution + HEK293 whole cell lysate

Anti-XIAP antibody [2F1] - ab28151 from Abcam

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F1
ab28151 staining XIAP in Mouse colonic epithelial cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with 0.01% Triton X-100 and blocked with 1% BSA for 45 minutes at 20°C. Samples were incubated with primary antibody (1/50 in 1% BSA + 0.01% Triton X-100) for 2 hours at 22°C. An Alexa Fluor® 488-conjugated Chicken anti-mouse IgG polyclonal (1/200) was used as the secondary antibody.See Abreview

Anti-XIAP antibody [MM0957-19P11] - ab201625 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0957-19P11

Anti-XIAP antibody - N-terminal - ab86229 from Abcam

Prices $359.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-XIAP antibody - N-terminal (ab86229) at 1/100 dilution + Mouse liver tissue lysate at 12.5 µg

Anti-XIAP Antibody (aa240) - LS-C18559 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XIAP Antibody - LS-C18562 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XIAP Antibody (C-Terminus) - LS-C18565 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XIAP Antibody (C-Terminus) - LS-C18566 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more