MRE11A

Gene Symbol	MRE11A
Entrez Gene	4361
Alt Symbol	ATLD, HNGS1, MRE11, MRE11B
Species	Human
Gene Type	protein-coding
Description	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Other Description	AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A
Swissprots	O43475 B3KTC7 P49959
Accessions	AAK18790 AAS79320 CCQ43331 EAW66930 EAW66931 EAW66932 EAW66933 EAW66934 P49959 AF022778 AAD10197 AF073362 AAC36249 AK095388 BAG53039 AK308318 BC005241 AAH05241 BC017823 AAH17823 BC063458 AAH63458 BF574168 BT006730 AAP35376 JF432288 ADZ15505 U37359 AAC78721 XM_005274008 XP_005274065 XM_006718842 XP_006718905 XM_011542837 XP_011541139 XR_947828 NM_005590 NP_005581 NM_005591 NP_005582
Function	Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Subcellular Location	Nucleus {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Top Pathways	Homologous recombination, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-MRE11A / MRE11 (Ser264) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1434 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat MRE11A / MRE11 ELISA Kit (Cell-Based ELISA) - LS-F2169 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Rabbit anti-Mre11 Antibody, Affinity Purified - PLA0057 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

MRE11 Colorimetric Cell-Based ELISA Kit - CB5470 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

MRE11 (Phospho-Ser264) Colorimetric Cell-Based ELISA Kit - CBP1472 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

MRE11 meiotic recombination 11 homolog A (S. cerevisiae) , ELISA Kit - MBS9336466 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.625ng/ml-20ng/ml.

MRE11 ELISA Kit - DEIA-XYA1233 from Creative Diagnostics Category ELISA Kit

MRE11 (Phospho-Ser264) ELISA Kit - DEIA-XYA1234 from Creative Diagnostics Category ELISA Kit

Human MRE11 ELISA Kit - E090102 from Biobool Category ELISA Kit

Human Double-strand break repair protein MRE11A (MRE11A) ELISA Kit - AE33022HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9355747 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9343485 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9350768 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9344523 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9358479 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9367766 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9343824 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9368714 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9363118 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9359542 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9358272 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9349741 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9345606 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9366146 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Double-Strand Break Repair Protein MRE11A (MRE11A), ELISA Kit - MBS9353890 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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