| Gene Symbol |
MRE11A
|
| Entrez Gene |
4361
|
| Alt Symbol |
ATLD, HNGS1, MRE11, MRE11B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
|
| Other Description |
AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A
|
| Swissprots |
O43475 B3KTC7 P49959
|
| Accessions |
AAK18790 AAS79320 CCQ43331 EAW66930 EAW66931 EAW66932 EAW66933 EAW66934 P49959 AF022778 AAD10197 AF073362 AAC36249 AK095388 BAG53039 AK308318 BC005241 AAH05241 BC017823 AAH17823 BC063458 AAH63458 BF574168 BT006730 AAP35376 JF432288 ADZ15505 U37359 AAC78721 XM_005274008 XP_005274065 XM_006718842 XP_006718905 XM_011542837 XP_011541139 XR_947828 NM_005590 NP_005581 NM_005591 NP_005582
|
| Function |
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
|
| Top Pathways |
Homologous recombination, Non-homologous end-joining
|