PMEL

Gene Symbol	PMEL
Entrez Gene	6490
Alt Symbol	D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100
Species	Human
Gene Type	protein-coding
Description	premelanosome protein
Other Description	melanocyte protein PMEL|melanocyte protein Pmel 17|melanocyte protein mel 17|melanocytes lineage-specific antigen GP100|melanoma-associated ME20 antigen|melanosomal matrix protein17|silver locus protein homolog|silver, mouse, homolog of
Swissprots	P40967 Q12763 B3KS57 Q16565 Q14448 B7Z6D7 Q14817
Accessions	AAB00386 AAB19181 CAD10318 CCQ43382 EAW96852 EAW96853 EAW96854 EAW96855 P40967 AK092881 BAG52619 AK130180 AK300150 BAH13223 BC001414 AAH01414 BT007202 AAP35866 CA432578 DA035117 DA633173 EU176186 ABW03637 M32295 AAA35930 M77348 AAA60121 S73003 AAC60634 U01874 AAA18479 XM_006719569 XP_006719632 XM_011538685 XP_011536987 XM_011538686 XP_011536988 XM_011538687 XP_011536989 NM_001200053 NP_001186982 NM_001200054 NP_001186983 NM_006928 NP_008859
Function	Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. {ECO:0000269|PubMed:11694580, ECO:0000269|PubMed:21962903}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes.
Tissue Specificity	Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas. Normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Melanoma gp100 full length protein - ab132146 from Abcam Category Protein Source Wheat germ Species Human

Human Melanoma gp100 protein fragment - ab38124 from Abcam Category Protein Source E. coli Species Human

PMEL / SILV / gp100 Antibody Blocking Peptide - LS-E2676 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PMEL / SILV / gp100 Antibody Blocking Peptide - LS-E17022 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PMEL / SILV / gp100 Antibody Blocking Peptide - LS-E26122 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PMEL17/SILV Protein - H00006490-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SILV-Antibody-Center-Blocking-peptide - BP13753c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

G154-gp100-154-162 - SP2306b from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

G154-gp100-154-162 - SP2306a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 500 µg

gp100-177-186 - SP2156b from Abgent, a WuXi AppTec company Category Peptide Prices $410.00 Sizes 5 mg

gp100-177-186 - SP2156a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

gp100-476-485 - SP2456b from Abgent, a WuXi AppTec company Category Peptide Prices $350.00 Sizes 5 mg

gp100-476-485 - SP2456a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Melanoma gp100 blocking peptide - GTX89304-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Human PMEL protein - orb245990 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PMEL protein - orb244541 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

gp100 (614622) peptide - orb70692 from Biorbyt Category Peptide Prices $332.00 Sizes 5 mg

gp100 (476-485) peptide - orb70690 from Biorbyt Category Peptide Prices $357.00 Sizes 5 mg

SILV Blocking Peptide - 33R-3727 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Melanoma gp100 Peptide - AC21-0951-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Melanoma gp100 - H00006490-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Melanoma gp100 - H00006490-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Pmel-17 Peptide - 46-204P from ProSci Category Peptide Species Human

SILV fusion protein - Ag6708 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SILV fusion protein - Ag6726 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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