Gene Symbol | CLPX |
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Entrez Gene | 10845 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | caseinolytic mitochondrial matrix peptidase chaperone subunit |
Other Description | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial|ClpX caseinolytic peptidase X homolog|ClpX caseinolytic protease X homolog|energy-dependent regulator of proteolysis |
Swissprots | A8K8F1 B9EGI8 O76031 Q9H4D9 A1L428 |
Accessions | CAC01291 EAW77715 EAW77716 O76031 AJ006267 CAA06933 AK292316 BAF85005 AK308133 AK310614 AL136922 CAB66856 BC130373 AAI30374 BC136487 AAI36488 BC144166 XM_011521164 XP_011519466 XR_931743 NM_006660 NP_006651 |
Function | ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:22710082, ECO:0000269|PubMed:22841477}. |
Subcellular Location | Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. |
Tissue Specificity | Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas. {ECO:0000269|PubMed:11003706}. |
CLPX (L-15) - sc-162691 from Santa Cruz Biotechnology
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CLPX (S-14) - sc-162692 from Santa Cruz Biotechnology
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Anti-CLPX antibody - ab122644 from Abcam
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Anti-CLPX antibody - ab123110 from Abcam
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Anti-CLPX antibody [EP8772] - ab168338 from Abcam
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Anti-CLPX Antibody (aa452-481, APC) - LS-C213336 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481, AP) - LS-C213335 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481, Biotin) - LS-C213337 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481, FITC) - LS-C213338 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481, PE) - LS-C213339 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481, Azide-free, HRP) - LS-C213340 from LifeSpan Bioscience
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Anti-CLPX Antibody (C-Terminus) - LS-C146170 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481) - LS-C320457 from LifeSpan Bioscience
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Anti-CLPX Antibody (aa452-481) - LS-C168856 from LifeSpan Bioscience
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CLPX Antibody - NBP1-89478 from Novus Biologicals
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Anti-CLPX antibody produced in rabbit - SAB2107784 from Sigma-Aldrich
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ANTI-CLPX (C-TERM) antibody produced in rabbit - SAB1303071 from Sigma-Aldrich
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Anti-CLPX antibody produced in rabbit - HPA040262 from Sigma-Aldrich
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CLPX antibody - C-terminal region (ARP63432_P050) - ARP63432_P050 from Aviva Systems Biology
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CLPX Antibody - C-terminal region (OAAB00784) - OAAB00784 from Aviva Systems Biology
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CLPX-Antibody-C-term - AP10767b from Abgent, a WuXi AppTec company
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CLPX antibody - GTX53477 from GeneTex
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CLPX antibody - orb28695 from Biorbyt
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Anti -CLPX, CT (CLPX, ATP-dependent Clp protease ATP-binding subunit clpX-like,mitochondrial) - 034014 from USBiological Life Science
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Anti -CLPX, CT (CLPX, ATP-dependent Clp protease ATP-binding subunit clpX-like,mitochondrial) (AP) - 034014-AP from USBiological Life Science
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