| Gene Symbol |
Pitpnm1
|
| Entrez Gene |
18739
|
| Alt Symbol |
DRES9, Mpt-1, Nir-2, PITPnm 1, Pitpnm, R75447, Rd9, RdgB, RdgB1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol transfer protein, membrane-associated 1
|
| Other Description |
drosophila retinal degeneration B homolog 1|membrane-associated phosphatidylinositol transfer protein 1|pyk2 N-terminal domain-interacting receptor 2|retinal degeneration 9
|
| Swissprots |
O35954
|
| Accessions |
EDL33005 EDL33006 O35954 AF006467 AAB84393 AK155377 AK177924 AK179862 AK180862 AK181080 AK183265 AK185797 AK185978 AK187966 AK188056 AK188396 AK188611 AK189965 AK190036 AK191918 AK193202 AK197131 AK200548 AK200663 AK203273 AK203300 AK203418 AK204841 AK207185 AK208861 AK209641 AK210105 AK210471 AK212016 AK212060 AK212517 AK217085 AK218358 AK219948 BC044893 AAH44893 BC048150 AAH48150 BY245171 BY261372 CJ097166 X98655 Y08922 CAA70127 XM_006531680 XP_006531743 XM_011251509 XP_011249811 XR_388251 XR_388252 XR_882621 XR_882622 NM_001136078 NM_008851 NP_032877 NR_075078
|
| Function |
Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Detected at high levels in brain, and at lower levels in lung, kidney, spleen and liver (at protein level). Ubiquitous. Highly expressed in embryonic retina and the central nervous system. {ECO:0000269|PubMed:9245688, ECO:0000269|PubMed:9680295}.
|