SCN5A

Gene Symbol	SCN5A
Entrez Gene	6331
Alt Symbol	CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1
Species	Human
Gene Type	protein-coding
Description	sodium channel, voltage gated, type V alpha subunit
Other Description	cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit|sodium channel protein cardiac muscle subunit alpha|sodium channel protein type 5 subunit alpha|sodium channel, voltage-gated, type V, alpha subunit|voltage-gated sodium channel subunit alpha Nav1.5
Swissprots	E7ET19 B2RTU0 A6N922 Q75RX9 E9PEK2 Q8IZC9 Q86UR3 Q14524 A6N923 Q59H93 Q96J69 Q75RY0 E9PFW7 E9PEF3 A5H1P8
Accessions	AAZ06802 ABN05288 ABO31246 ABQ01244 ADC96632 EAW64540 EAW64541 EAW64542 Q14524 AB158469 BAD12084 AB158470 BAD12085 AB208866 BAD92103 AF482988 AAO91669 AJ310886 CAC84529 AJ310887 CAC84530 AJ310888 CAC84531 AJ310889 CAC84532 AJ310890 CAC84533 AJ310891 CAC84534 AJ310892 CAC84535 AJ310893 CAC84525 AJ310894 AJ310895 AJ310896 CAC84536 AY038064 AAK74065 AY148488 AAN61120 BC051374 AAH51374 BC140813 AAI40814 BC144621 AAI44622 BU845010 EF092292 ABN50061 EF092293 ABN50062 EF092294 ABN50063 EF092295 ABN50064 EF629346 ABR15763 EF629347 ABR15764 GU014840 ACX32327 GU447319 GU447320 KC858891 AGR66220 M77235 AAA58644 XM_006713282 XP_006713345 XM_011533991 XP_011532293 XM_011533992 XP_011532294 NM_000335 NP_000326 NM_001099404 NP_001092874 NM_001099405 NP_001092875 NM_001160160 NP_001153632 NM_001160161 NP_001153633 NM_198056 NP_932173
Function	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. {ECO:0000269|PubMed:19074138}.
Subcellular Location	Membrane {ECO:0000269|PubMed:19074138}; Multi-pass membrane protein {ECO:0000269|PubMed:19074138}.
Tissue Specificity	Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain. {ECO:0000269|PubMed:12358675}.
Top Pathways	Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nav1.5 full length protein - ab132328 from Abcam Category Protein Source Wheat germ Species Human

Human Nav1.5 peptide - ab96114 from Abcam Category Peptide

Nav1.5 peptide (1548-1558) - ab45808 from Abcam Category Peptide Species Human

SCN5A / Nav1.5 Antibody Blocking Peptide - LS-E6258 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SCN5A / Nav1.5 Antibody Blocking Peptide - LS-E27655 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SCN5A / Nav1.5 Antibody Blocking Peptide - LS-E25942 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SCN5A / Nav1.5 Antibody Blocking Peptide - LS-E12443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SCN5A / Nav1.5 Antibody Blocking Peptide - LS-E29705 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Nav1.5 Protein - H00006331-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SCN5A-Antibody-N-term-Blocking-Peptide - BP18938a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Nav1.5 blocking peptide - GTX89500-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

SCN5A Blocking Peptide - 33R-3093 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SCN5A Blocking Peptide - 33R-8381 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Nav1.5 Peptide - AC21-0771-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Nav1.5 Peptide - AC21-2472-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SCN5A - H00006331-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SCN5A - H00006331-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SCN5A Peptide - 42-840P from ProSci Category Peptide

SCN5A Peptide - 46-343P from ProSci Category Peptide

SCN5A fusion protein - ag18450 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SCN5A fusion protein - Ag19275 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SCN5A, His-tagged - SCN5A-2537H from Creative Biomart Category Protein Source E.coli Species Human

SCN5A, Peptide - MBS428387 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

SCN5A, Peptide - MBS427706 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

SCN5A Peptide, Human - M34GP13872H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more